High concentrations of several metabolites and growth factors in patients with delayed lower limb fracture healing

摘要

Purpose To study concentrations of metabolites and growth factors as well as hematological parameters in patients with delayed lower limb fracturehealing Material and methods Concentrations of several metabolites and growth factors as well as hematological parameters were studied in 13 patientswith a delay in healing of femoral and tibial fractures after 7 to 11 months following injury. Seven patients with consolidated diaphyseal femoral and tibialfractures examined 10 to 12 months after the injury were a control group. Ten healthy subjects that did not have any history of fractures were a referencegroup. Results Unlike individuals of control and reference groups, patients with delayed fracture healing showed significantly higher concentrations oflactate, triglycerides, TGF-α and TGF-β2 in their serum while IGF-1 levels were significantly lower. Hematology tests did not show differences betweenthe groups. Conclusion Local hypoxia, acidosis and expression of GFs that support osteolysis were the main pathophysiological processes that could causethe delay in long-bone fracture healing.