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Targeting MEK5 impairs nonhomologous end-joining repair and sensitizes prostate cancer to DNA damaging agents

机译：瞄准MEK5损害非症状终端连接修复并敏感前列腺癌对DNA损伤剂

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Constantinos G. Broustas; Axel J. Duval; Kunal R. Chaudhary; Richard A. Friedman; Renu K. Virk; Howard B. Lieberman;
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1. Targeting MEK5 impairs nonhomologous end-joining repair and sensitizes prostate cancer to DNA damaging agents [J] . Constantinos G. Broustas, Axel J. Duval, Kunal R. Chaudhary, Oncogene . 2020,第12期

机译：靶向MEK5会损害非同源末端连接修复并使前列腺癌对DNA破坏剂敏感
2. Selective inhibitors of nuclear export (SINE) block the expression of DNA damage repair proteins and sensitize cancer cells to DNA damage therapeutic agents [J] . Kashyap T., Crochiere M., Friedlander S., European journal of cancer: official journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR) . 2014,第Suppla6期

机译：核输出的选择性抑制剂（SINE）阻止DNA损伤修复蛋白的表达并使癌细胞对DNA损伤治疗剂敏感
3. Cyclin D1 silencing suppresses tumorigenicity, impairs DNA double strand break repair and thus radiosensitizes androgen-independent prostate cancer cells to DNA damage [J] . Francesco Marampon, Giovanni Luca Gravina, Claudio Festuccia, Italian Journal of Anatomy and Embryology . 2016,第1期

机译：细胞周期蛋白D1沉默抑制致瘤性，损害DNA双链断裂修复，从而使雄激素无关的前列腺癌细胞与DNA损伤
4. Repairing DNA double-strand breaks by the prokaryotic non-homologous end-joining pathway [C] . Nigel C. Brissett, Aidan J. Doherty Biochemical Society Symposium . 2009

机译：通过原核非同源终端连接途径修复DNA双链断裂
5. Overexpression of nuclear and mitochondrial-targeted MPG sensitizes breast cancer cells to chemotherapeutic agents and results in an imbalance in DNA repair [D] . Limp-Foster, Melissa M. 2001

机译：核和线粒体靶向的MPG的过表达使乳腺癌细胞对化疗药物敏感并导致DNA修复失衡
6. Selinexor reduces the expression of DNA damage repair proteins and sensitizes cancer cells to DNA damaging agents [O] . Trinayan Kashyap, Christian Argueta, Thaddeus Unger, 2018

机译：Selinexor降低DNA损伤修复蛋白的表达并使癌细胞对DNA损伤剂敏感
7. Targeting MEK5 impairs non-homologous end-joining repair and sensitizes prostate cancer to DNA damaging agents [O] . Constantinos G. Broustas, Axel J. Duval, Kunal R. Chaudhary, 2019

机译：瞄准MEK5损害无同性恋的终端连接修复并敏感前列腺癌对DNA损伤剂

Targeting MEK5 impairs nonhomologous end-joining repair and sensitizes prostate cancer to DNA damaging agents

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