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Targeted CRISPR screening identifies PRMT5 as synthetic lethality combinatorial target with gemcitabine in pancreatic cancer cells

机译：有针对性的CRISPR筛选将PRMT5鉴定为胰腺癌细胞中吉西他滨的合成致死性组合靶标

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Xiaolong Wei; Jiekun Yang; Sara J. Adair; Cem Kuscu; Kyung Yong Lee; William Kane; Patrick O’hara; Denis Liu; Yusuf Mert Demirlenk; Alaa Hamdi Habieb; Ebru Yilmaz; Anindya Dutta; Todd W. Bauer; Mazhar Adli;
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1. Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer [J] . David O Azorsa, Irma M Gonzales, Gargi D Basu, Journal of Translational Medicine . 2009,第1期

机译：合成致死性RNAi筛选确定了吉西他滨治疗胰腺癌的敏化靶标
2. CRISPR knockout screening identifies combinatorial drug targets in pancreatic cancer and models cellular drug response [J] . Karol Szlachta, Cem Kuscu, Turan Tufan, Nature Communications . 2018,第1期

机译：CRISPR基因敲除筛选可识别胰腺癌的组合药物靶标并模拟细胞药物反应
3. A synthetic lethal screen identifies the Vitamin D receptor as a novel gemcitabine sensitizer in pancreatic cancer cells [J] . Bhattacharjee V., Zhou Y., Yen T. J. Cell cycle . 2014,第24期

机译：合成致死筛查确定维生素D受体是胰腺癌细胞中的新型吉西他滨敏化剂
4. A Phenotypic Screening Approach to Identify Antibody-Tractable Targets in Pancreatic Cancer [C] . Andrea Gonzalez-Munoz, Hannah Thompson, Louise Slater, PEGS . 2014

机译：一种鉴定胰腺癌抗体 - 易靶标的表型筛选方法
5. Identifying Novel Inhibitors of Epithelial to Mesenchymal Transition (EMT) for Targeting Pancreatic Cancer Metastasis and Cancer Stem Cells [D] . Polireddy, Kishore. 2015

机译：确定靶向胰腺癌转移和癌症干细胞的新型上皮间质转化抑制剂（EMT）
6. Targeted CRISPR screening identifies PRMT5 as synthetic lethality combinatorial target with gemcitabine in pancreatic cancer cells [O] . Xiaolong Wei, Jiekun Yang, Sara J. Adair, 2020

机译：有针对性的CRISPR筛选将PRMT5鉴定为胰腺癌细胞中吉西他滨的合成致死性组合靶标
7. Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer [O] . David O Azorsa, Irma M Gonzales, Gargi D Basu, 2009

机译：合成致死RNAi筛选确定了吉西他滨治疗胰腺癌的敏化靶标

Targeted CRISPR screening identifies PRMT5 as synthetic lethality combinatorial target with gemcitabine in pancreatic cancer cells

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