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Hypoxia-Selective O6-Alkylguanine-DNA Alkyltransferase Inhibitors: Design, Synthesis, and Evaluation of 6-(Benzyloxy)-2-(aryldiazenyl)-9H-purines as Prodrugs of O6-Benzylguanine

机译：缺氧 - 选择性O6-烷基胍胺-DNA烷基转移酶抑制剂：6-（苄氧基）-2-（芳基二亚苯基）-9H-嘌呤的设计，合成和评价为O6-苄基吉隆的前药

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Rui Zhu; Raymond P. Baumann; Philip G. Penketh; Krishnamurthy Shyam; Alan C. Sartorelli;
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1. Hypoxia-selective O~6-alkylguanine-DNA alkyltransferase inhibitors: Design, synthesis, and evaluation of 6-(benzyloxy)-2-(aryldiazenyl)- 9H -purines as prodrugs of O~6-benzylguanine [J] . Zhu R., Baumann R.P., Penketh P.G., Journal of Medicinal Chemistry . 2013,第3期

机译：缺氧选择性O〜6-烷基鸟嘌呤-DNA烷基转移酶抑制剂：6-（苄氧基）-2-（芳基二氮烯基）-9H-嘌呤作为O〜6-苄基鸟嘌呤的前药的设计，合成和评价
2. O6-alkylguanine-DNA alkyltransferase inactivation by ester prodrugs of O6-benzylguanine derivatives and their rate of hydrolysis by cellular esterases. [J] . Dolan ME, Roy SK, Garbiras BJ, Biochemical Pharmacology . 1998,第10期

机译：O6-苄基鸟嘌呤衍生物的酯前药使O6-烷基鸟嘌呤-DNA烷基转移酶失活，以及它们被细胞酯酶水解的速率。
3. Synthesis and preliminary biological evaluation of the derivatives of O6-benzylguanine as inactivators of O6-alkylguanine-DNA alkyltransferase [J] . Lei Zhang, Bing Jia, Chang Feng Hu, 中国化学快报（英文版） . 2008,第007期

机译：作为O6-烷基鸟嘌呤-DNA烷基转移酶灭活剂的O6-苄基鸟嘌呤衍生物的合成及初步生物学评价
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6. Hypoxia-selective O6-Alkylguanine-DNA Alkyltransferase Inhibitors: Design Synthesis and Evaluation of 6-(Benzyloxy)-2-(aryldiazenyl)-9H-purines as Prodrugs of O6-Benzylguanine [O] . Rui Zhu, Raymond P. Baumann, Philip G. Penketh, -1

机译：低氧选择性O6-烷基鸟嘌呤-DNa烷基抑制剂：设计合成和6-评价（苄氧基）-2-（aryldiazenyl）-9H-嘌呤作为O6苄基鸟嘌呤的前药
7. Design of a hypoxia-activated prodrug inhibitor of O6-alkylguanine-DNA alkyltransferase [O] . Rui Zhu, Helen A. Seow, Raymond P. Baumann, 2012

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Hypoxia-Selective O6-Alkylguanine-DNA Alkyltransferase Inhibitors: Design, Synthesis, and Evaluation of 6-(Benzyloxy)-2-(aryldiazenyl)-9H-purines as Prodrugs of O6-Benzylguanine

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