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In Silico Simulation of the Systemic Drug Exposure Following the Topical Application of Opioid Analgesics in Patients with Cutaneous Lesions

机译：在皮肤病患者的阿片类镇痛药物局部应用后的Silico模拟系统药物暴露

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Maksim Khotimchenko; Victor Antontsev; Kaushik Chakravarty; Hypatia Hou; Jyotika Varshney;
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年度 2021
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1. Should topical opioid analgesics be regarded as effective and safe when applied to chronic cutaneous lesions? [J] . Farley P Journal of Pharmacy and Pharmacology . 2011,第6期

机译：外用阿片类镇痛药应用于慢性皮肤病变是否应被视为安全有效？
2. Analgesic synergy between topical opioids and topical non-steroidal anti-inflammatory drugs in the mouse model of thermal pain. [J] . Kolesnikov Y, Soritsa D European Journal of Pharmacology: An International Journal . 2008,第1a3期

机译：在热痛小鼠模型中，局部阿片类药物和局部非甾体类抗炎药之间的镇痛协同作用。
3. Combining machine learning and mechanistic modeling approaches to solve real life problems - assessment of the local tissue binding and its influence on the systemic exposure after topical application of drugs [J] . Polak Sebastian, Mendyk Aleksander, Patel Nikunjkumar Journal of pharmacokinetics and pharmacodynamics . 2018,第Suppla期

机译：结合机械学习和机械建模方法解决现实生活问题 - 局部组织结合的评估及其对局部应用局部应用后的全身暴露
4. Bifunctional Peptides with a μ/δ Opioid Activity Profile as Analgesic Drug Candidates with Reduced Side Effects [C] . Jinguo Ding, Thi M.-D. Nguyen, Carole Lemieux, Chinese International Peptide Symposium . 2013

机译：双官能肽具有μ/δ阿片类活性型材作为镇痛药物候选者，副作用减少
5. A Quality Improvement Project to Standardize Opioid Analgesic Pain Management for Carpal Tunnel Release Surgical Patients by Implementation of a Pre-op Evidence-Based Educational Session [D] . Markow, Rachel. 2019

机译：一种质量改进项目，以规范表阿片镇痛疼痛管理，通过实施综合循证循证教育课程释放手术患者
6. In Silico Simulation of the Systemic Drug Exposure Following the Topical Application of Opioid Analgesics in Patients with Cutaneous Lesions [O] . Maksim Khotimchenko, Victor Antontsev, Kaushik Chakravarty, 2021

机译：在皮肤病患者的阿片类镇痛药物局部应用后的Silico模拟系统药物暴露
7. Inhibition of Cutaneous Contact Hypersensitivity in the Mouse with Systemic or Topical Spiperone: Topical Application of Spiperone Produces Local Immunosuppression Without Inducing Systemic Neuroleptic Effects [O] . Sharpe Richard J, Chandrasekar Akila, Arndt Kenneth A, 1992

机译：全身或局部使用螺per酮对小鼠皮肤接触性超敏反应的抑制作用：局部使用螺per酮可产生局部免疫抑制作用，而不会引起全身性精神抑制药作用

In Silico Simulation of the Systemic Drug Exposure Following the Topical Application of Opioid Analgesics in Patients with Cutaneous Lesions

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