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CRISPR DNA base editors with reduced RNA off-target and self-editing activities

机译：CRISPR DNA基础编辑编辑降低RNA脱靶和自我编辑活动

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Julian Grünewald; Ronghao Zhou; Sowmya Iyer; Caleb A. Lareau; Sara P. Garcia; Martin J. Aryee; J. Keith Joung;
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1. CRISPR DNA base editors with reduced RNA off-target and self-editing activities [J] . Grunewald Julian, Zhou Ronghao, Iyer Sowmya, Nature biotechnology . 2019,第9期

机译：CRISPR DNA基础编辑以降低RNA脱靶和自我编辑活动
2. Transcriptome-wide off-target RNA editing induced by CRISPR-guided DNA base editors [J] . Grunewald Julian, Zhou Ronghao, Garcia Sara P., Nature . 2019,第7756期

机译：CRISPR引导的DNA基础编辑器诱导的转录组范围外脱靶RNA编辑
3. Transcriptome-wide off-target RNA editing induced by CRISPR-guided DNA base editors [J] . Grunewald Julian, Zhou Ronghao, Garcia Sara P., Nature . 2019,第7756期

机译：通过CRISPR引导的DNA碱基编辑诱导的转录组偏移偏移RNA编辑
4. Reduced base-base interactions between the DNA seed and RNA target are the major determinants of a significant reduction in the off-target effect due to DNA-seed-containing siRNA [C] . Ui-Tei K., Nishi K., Naito Y., Micro-NanoMechatronics and Human Science, 2009. MHS 2009 . 2009

机译：DNA种子与RNA靶之间的碱基间相互作用降低是由于含DNA种子的siRNA导致脱靶效应显着降低的主要决定因素
5. Utilities for Off-Target DNA Mining in Non-Model Organisms and Querying for Phylogenetic Patterns [D] . Mechtley, Alisha. 2018

机译：非模型生物中脱靶机DNA挖掘的公用事业和系统发育模式的查询
6. CRISPR/Cas9 systems have off-target activity with insertions or deletions between target DNA and guide RNA sequences [O] . Yanni Lin, Thomas J. Cradick, Matthew T. Brown, -1

机译：CRISPR / Cas9系统具有脱靶活性在靶DNA和指导RNA序列之间有插入或缺失
7. Engineering domain-inlaid SaCas9 adenine base editors with reduced RNA off-targets and increased on-target DNA editing [O] . Minh Thuan Nguyen Tran, Mohd Khairul Nizam Mohd Khalid, Qi Wang, 2020

机译：工程域镶嵌Saca9腺嘌呤基础编辑器，具有降低的RNA脱靶并增加目标DNA编辑

CRISPR DNA base editors with reduced RNA off-target and self-editing activities

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