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Discovery of Potent and Selective Tricyclic Inhibitors of Bruton’s Tyrosine Kinase with Improved Druglike Properties

机译：发现Bruton酪氨酸激酶有效和选择性三环抑制剂，具有改进的药物性能

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Xiaojing Wang; James Barbosa; Peter Blomgren; Meire C. Bremer; Jacob Chen; James J. Crawford; Wei Deng; Liming Dong; Charles Eigenbrot; Steve Gallion; Jonathon Hau; Huiyong Hu; Adam R. Johnson; Arna Katewa; Jeffrey E. Kropf; Seung H. Lee; Lichuan Liu; Joseph W. Lubach; Jen Macaluso; Pat Maciejewski; Scott A. Mitchell; Daniel F. Ortwine; Julie DiPaolo; Karin Reif; Heleen Scheerens; Aaron Schmitt; Harvey Wong; Jin-Ming Xiong; Jianjun Xu; Zhongdong Zhao; Fusheng Zhou; Kevin S. Currie; Wendy B. Young;
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1. Discovery of highly potent and selective Bruton's tyrosine kinase inhibitors: Pyridazinone analogs with improved metabolic stability [J] . Young Wendy B., Barbosa James, Blomgren Peter, Bioorganic and Medicinal Chemistry Letters . 2016,第2期

机译：发现高效和选择性的布鲁顿酪氨酸激酶抑制剂：具有改善的代谢稳定性的哒嗪酮类似物
2. Discovery of potent and highly selective covalent inhibitors of Bruton's tyrosine kinase bearing triazine scaffold [J] . Teng Yu, Lu Xiang, Xiao Maoxu, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2020,第1期

机译：发现丰富且具有高度选择性的Bruton酪氨酸激酶轴承三嗪脚手架的共价抑制剂
3. Discovery of LOU064 (Remibrutinib), a Potent and Highly Selective Covalent Inhibitor of Bruton's Tyrosine Kinase [J] . Angst Daniela, Gessier Francois, Janser Philipp, Journal of Medicinal Chemistry . 2020,第10期

机译：LOU064（Rembribrutinib），富乐酪氨酸激酶的有效和高度选择性的共价抑制剂的发现
4. CNX-774, an Irreversible, Selective and Orally Bioavailable Inhibitor of Bruton's Tyrosine Kinase: In Vitro ADME, Selectivity, and Pharmacokinetic Properties [C] . Prasoon Chaturvedi, Matthew Labenski, Erica Evans, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2011

机译：CNX-774，Bruton的酪氨酸激酶的不可逆转，选择性和口服生物可利用的抑制剂：体外Adme，选择性和药代动力学性能
5. Pharmacological Characterization of TAS05567, a Potent and Selective Inhibitor of Spleen Tyrosine Kinase, in Animal Models of Inflammatory Diseases and B-cell Malignancies [D] . 林宏明 2019

机译：TAS05567，脾酪氨酸激酶的强效和选择性抑制剂，在炎症性疾病和B细胞恶性动物模型中的药理特性
6. Discoveryof Potent and Selective Tricyclic Inhibitors of Bruton’s TyrosineKinase with Improved Druglike Properties [O] . Xiaojing Wang, *, James Barbosa, 2017

机译：发现顿酪氨酸的强效和选择性三环抑制剂的合成具有改善的类药物特性的激酶
7. Discovery of a highly potent and selective Bruton’s tyrosine kinase inhibitor avoiding impairment of ADCC effects for B-cell non-Hodgkin lymphoma [O] . Juan Liu, Qianmao Liang, Aoli Wang, 2020

机译：发现高度有效和选择性的Bruton的酪氨酸激酶抑制剂避免了B细胞非霍奇金淋巴瘤的ADCC效应的损害

Discovery of Potent and Selective Tricyclic Inhibitors of Bruton’s Tyrosine Kinase with Improved Druglike Properties

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