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Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases ?-cleavage of amyloid precursor protein and amyloid-? production in vivo

机译：口服施用有效和选择性的非肽BACE-1抑制剂抑制剂减少了α-淀粉样蛋白前体蛋白和淀粉样蛋白 - β-α在体内生产

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Ishrut Hussain; Julie Hawkins; David Harrison; Christopher Hille; Gareth Wayne; Leanne Cutler; Tania Buck; Daryl Walter; Emmanuel Demont; Colin Howes; Alan Naylor; Philip Jeffrey; Maria I. Gonzalez; Colin Dingwall; Anton Michel; Sally Redshaw; John B. Davis;
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1. Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases beta-cleavage of amyloid precursor protein and amyloid-beta production in vivo. [J] . Hussain I, Hawkins J, Harrison D, Journal of Neurochemistry: Offical Journal of the International Society for Neurochemistry . 2007,第3期

机译：口服和有效的选择性非肽类BACE-1抑制剂可减少体内淀粉样蛋白前体蛋白的β切割和淀粉样β的产生。
2. Binding of F-spondin to amyloid-β precursor protein: A candidate amyloid-β precursor protein ligand that modulates amyloid-β precursor protein cleavage [J] . Angela Ho, Thomas C. Suedhof Proceedings of the National Academy of Sciences of the United States of America . 2004,第8期

机译：F-spondin与淀粉样β前体蛋白的结合：候选淀粉样β前体蛋白配体，可调节淀粉样β前体蛋白的裂解。
3. Discovery of AM-6494: A Potent and Orally Efficacious beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor with in Vivo Selectivity over BACE2 [J] . Pettus Liping H., Bourbeau Matthew P., Bradley Jodi, Journal of Medicinal Chemistry . 2020,第5期

机译：AM-6494的发现：一种有效和口服的β-位点淀粉样蛋白前体蛋白质切割酶1（BACE1）抑制剂，具有在Bace2上的体内选择性
4. Pharmacophore Based Virtual Screening, Molecular Docking and Density Functional Theory Approaches to Discover the Potent Beta-Amyloid Precursor Protein (B-App) Inhibitor [C] . G. Shakila, C. Meganathan, N. Sundaraganesan, National Conference on Hierarchically Structured Materials . 2019

机译：基于Pharmacophore的虚拟筛选，分子对接和密度泛函理论方法，以发现有效的β-淀粉样蛋白前体蛋白（B-APP）抑制剂
5. beta-Endorphin inhibits the expression of amyloid precursor protein in SK-N-SH neuroblastoma cells expressing high levels of mutant amyloid precursor protein. [D] . Boggeti, Renuka. 2012

机译：β-内啡肽抑制表达高水平突变淀粉样蛋白前体蛋白的SK-N-SH神经母细胞瘤细胞中淀粉样蛋白前体蛋白的表达。
6. Binding of F-spondin to amyloid-β precursor protein: A candidate amyloid-β precursor protein ligand that modulates amyloid-β precursor protein cleavage [O] . Angela Ho, Thomas C. Südhof 2004

机译：F-spondin与淀粉样β前体蛋白的结合：候选淀粉样β前体蛋白配体可调节淀粉样β前体蛋白的裂解。
7. Binding of F-spondin to amyloid-β precursor protein: A candidate amyloid-β precursor protein ligand that modulates amyloid-β precursor protein cleavage [O] . Ho, Angela, Südhof, Thomas C. 2004

机译：F-spondin与淀粉样β前体蛋白的结合：候选淀粉样β前体蛋白配体，可调节淀粉样β前体蛋白的裂解。

Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases ?-cleavage of amyloid precursor protein and amyloid-? production in vivo

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