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Improving colon cancer therapy with a new promising small-molecule activator of the p53-pathway through disruption of p53-MDM2/MDMX interactions

机译：通过破坏P53-MDM2 / MDMX相互作用，通过破坏P53-途径的新有前途的小分子活化剂改善结肠癌治疗

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Liliana Raimundo; Lucília Saraiva; Margarida Espadinha; Joana Soares; Joana Loureiro; Juliana Calheiros; Nair Nazareth; Joana Almeida; Marco Alves; Maria Santos;
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1. The past, present and future of potential small-molecule drugs targeting p53-MDM2/MDMX for cancer therapy [J] . Liu Yao, Wang Xiaohui, Wang Guan, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2019,第期

机译：潜在的小分子药物的过去，现在和未来靶向P53-MDM2 / MDMX的癌症治疗
2. Oxazoloisoindollnones with in vitro antitumor activity selectively activate a p53-pathway through potential inhibition of the p53-MDM2 interaction [J] . Joana Soares, Nuno AX. Pereira, Angelo Monteiro, European journal of pharmaceutical sciences . 2015,第Null期

机译：具有体外抗肿瘤活性的恶唑烷二氢吲哚酮通过潜在抑制p53-MDM2相互作用选择性激活p53途径
3. Discovery of a small-molecule protein kinase Cδ-selective activator with promising application in colon cancer therapy [J] . Cláudia Bessa, Joana Soares, Liliana Raimundo, Cell death & disease. . 2018,第2期

机译：发现一种小分子蛋白激酶Cδ选择性激活剂，有望在结肠癌治疗中应用
4. Adjuvant Chemotherapy Should Not Routinely Be Recommended to Patients with Stage II Colon Cancers that Manifest Microsatellite Instability [C] . Sigurdis Haraldsdottir, Richard M. Goldberg Gastrointestinal Cancers Symposium . 2014

机译：不应常规向患有阶段结肠癌的患者常规的辅助化学疗法，表明微卫星不稳定性
5. Part I. A small-molecule library strategy for disruption of protein-protein interactions. Part II. Antibody-catalyzed anaerobic destruction of methamphetamine: A new direction in immunopharmacotherapy. Part III. Design and synthesis of reactive immunization haptens. [D] . Xu, Yang. 2007

机译：第一部分。破坏蛋白质间相互作用的小分子文库策略。第二部分甲基苯丙胺的抗体催化厌氧破坏：免疫药物治疗的新方向。第三部分反应性免疫半抗原的设计与合成。
6. Discovery of a small-molecule protein kinase Cδ-selective activator with promising application in colon cancer therapy [O] . Cláudia Bessa, Joana Soares, Liliana Raimundo, 2018

机译：发现一种小分子蛋白激酶Cδ选择性激活剂在结肠癌治疗中具有广阔的应用前景
7. Discovery of a small-molecule protein kinase Cδ-selective activator with promising application in colon cancer therapy [O] . Cláudia Bessa, Joana Soares, Liliana Raimundo, 2018

机译：发现小分子蛋白激酶Cδ选择性活化剂，在结肠癌治疗中有前景应用
8. Isolation of Factors That Disrupt Critical Protein/Protein Interactions Within the Telomerase Holoenzyme for Use in Breast Cancer Therapies [R] . White, M. A. 2003

机译：分离破坏端粒酶全酶中关键蛋白质/蛋白质相互作用的因子用于乳腺癌治疗

Improving colon cancer therapy with a new promising small-molecule activator of the p53-pathway through disruption of p53-MDM2/MDMX interactions

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