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Both BRCA1-wild type and -mutant triple-negative breast cancers show sensitivity to the NAE inhibitor MLN4924 which is enhanced upon MLN4924 and cisplatin combination treatment

机译：BRCA1-野生型和矫正器三重阴性乳腺癌均显示对NAE抑制剂MLN4924的敏感性，这在MLN4924和顺铂组合处理上增强

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Shrilekha Misra; Xiaoli Zhang; Nissar Ahmad Wani; Steven Sizemore; Alo Ray;
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1. AKT inhibitor MK-2206 sensitizes breast cancer cells to MLN4924, a first-in-class NEDD8-activating enzyme (NAE) inhibitor [J] . Chen Xiaoyu, Cui Danrui, Bi Yanli, Cell cycle . 2018,第16期

机译：AKT抑制剂MK-2206使乳腺癌细胞敏感至MLN4924，是一类阶级的NEDD8活化酶（NAE）抑制剂
2. Molecular dynamics investigation on the poor sensitivity of A171T mutant NEDD8-activating enzyme (NAE) for MLN4924 [J] . VermaS., SinghA., MishraA. Journal of Biomolecular Structure and Dynamics . 2014,第7a8期

机译：A171T突变体NEDD8活化酶（NAE）对MLN4924敏感性差的分子动力学研究
3. Molecular dynamics simulation on the low sensitivity of mutants of NEDD-8 activating enzyme for MLN4924 inhibitor as a cancer drug [J] . Behnam Rashidieh, Mohharam Valizadeh, Vahideh Assadollahi, American Journal of Cancer Research . 2015,第11期

机译：NEDD-8活化酶突变体对MLN4924抑制剂作为抗癌药敏感性低的分子动力学模拟
4. Synergistic Enhancement of Breast Cancer Cell Death Using Ultrasound-Microbubbles in Combination with Cisplatin [C] . Sheliza Jetha, Raffi Karshafian International Symposium on Therapeutic Ultrasound . 2017

机译：使用超声微泡与顺铂相结合使用超声微泡的乳腺癌细胞死亡协同增强
5. Repurposing Potassium Channel Inhibitors to Target Triple-Negative Breast Cancer [D] . Ram, Priyanka. 2021

机译：修复钾通道抑制剂以靶向三阴性乳腺癌
6. Both BRCA1-wild type and -mutant triple-negative breast cancers show sensitivity to the NAE inhibitor MLN4924 which is enhanced upon MLN4924 and cisplatin combination treatment [O] . Shrilekha Misra, Xiaoli Zhang, Nissar Ahmad Wani, 2020

机译：野生型BRCA1型和突变型三阴性乳腺癌均显示出对NAE抑制剂MLN4924的敏感性这种敏感性在MLN4924和顺铂联合治疗后得到增强
7. AKT inhibitor MK-2206 sensitizes breast cancer cells to MLN4924, a first-in-class NEDD8-activating enzyme (NAE) inhibitor [O] . Xiaoyu Chen, Danrui Cui, Yanli Bi, 2018

机译：AKT抑制剂MK-2206使乳腺癌细胞敏感至MLN4924，是一类阶级的NEDD8活化酶（NAE）抑制剂

Both BRCA1-wild type and -mutant triple-negative breast cancers show sensitivity to the NAE inhibitor MLN4924 which is enhanced upon MLN4924 and cisplatin combination treatment

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