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A Phase 2 Study of Neo-adjuvant Metformin and Temozolomide followed by Hypofractionated Accelerated RadioTherapy (HART) with Concomitant and Adjuvant Metformin and Temozolomide (TMZ) in Patients with Glioblastoma

机译：具有胶质母细胞瘤患者伴随的伴随的加速放射疗法（HART）和唑类二甲双胍（HART）胶质母细胞瘤患者伴随的加速放疗（HART）的2相2研究

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G. Shenouda; L. Souhami; K. Petrecca; V. Panet-Raymond; S. Owen; R.J. Diaz; J. Hall; M.C. Guiot; T. Carvalho; B.S. Abdulkarim;
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机译：Neoadjuvant Temozolomide（TMZ）的2阶段试验，然后加速低次级的放射治疗（AHRT）和TMZ，然后在新诊断的胶质母细胞瘤（GBM）患者中进行佐剂TMZ：长期存活和毒性分析
2. Hypofractionated accelerated radiotherapy (HART) with concurrent and adjuvant temozolomide in newly diagnosed glioblastoma: a phase II randomized trial (HART-GBM trial) [J] . Supriya Mallick, Haresh Kunhiparambath, Subhash Gupta, Journal of neuro-oncology. . 2018,第1期

机译：新诊断的胶质母细胞瘤中的并发和佐剂替替替替替莫替莫胺（HART）的加速加速放疗（HART）：II期随机试验（HART-GBM试验）
3. EORTC study 26041-22041: phase I/II study on concomitant and adjuvant temozolomide (TMZ) and radiotherapy (RT) with PTK787/ZK222584 (PTK/ZK) in newly diagnosed glioblastoma. [J] . Brandes AA, Stupp R, Hau European journal of cancer: official journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR) . 2010,第2期

机译：EORTC研究26041-22041：在新诊断的胶质母细胞瘤中，伴有替莫唑胺（TMZ）和放疗（PTK）与PTK787 / ZK222584（PTK / ZK）进行的I / II期研究。
4. A phase I study of vincristine, escalating doses of irinotecan, temozolomide and bevacizumab (VIT-B) in pediatric and adolescent patients with recurrent or refractory solid tumors of non-hematopoietic origin [D] . Venkatramani, Rajkumar. 2010

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5. ATNT-12PHASE I TWO-STAGE OPEN-LABEL DOSE-ESCALATION STUDY OF BUPARLISIB (BKM120) IN COMBINATION WITH ADJUVANT TEMOZOLOMIDE (TMZ) AND WITH CONCOMITANT RADIATION THERAPY (RT) AND TMZ IN PATIENTS WITH NEWLY DIAGNOSED GLIOBLASTOMA (GBM) [O] . Jordi Rodon, Mark Rosenthal, Warren Mason, 2015

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6. A Phase 2 Trial of Neoadjuvant Temozolomide (TMZ) Followed By Accelerated Hypofractionated Radiation Therapy (AHRT) and TMZ Followed By Adjuvant TMZ in Patients with Newly Diagnosed Glioblastoma (GBM): Long Term Survival and Toxicity Analysis [O] . G. Shenouda, L. Souhami, K. Petrecca, 2018

机译：Neoadjuvant Temozolomide（TMZ）的2阶段试验，然后加速低次级的放射治疗（AHRT）和TMZ，然后在新诊断的胶质母细胞瘤（GBM）患者中进行佐剂TMZ：长期存活和毒性分析

A Phase 2 Study of Neo-adjuvant Metformin and Temozolomide followed by Hypofractionated Accelerated RadioTherapy (HART) with Concomitant and Adjuvant Metformin and Temozolomide (TMZ) in Patients with Glioblastoma

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