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IL-2 Intratumoral Immunotherapy Enhances CD8+ T Cells That Mediate Destruction of Tumor Cells and Tumor-Associated Vasculature: A Novel Mechanism for IL-2

机译：IL-2肿瘤免疫疗法增强CD8 + T细胞，介导肿瘤细胞和肿瘤相关脉管系统的破坏：IL-2的新机制

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Connie Jackaman; Christine S. Bundell; Beverley F. Kinnear; Alison M. Smith; Pierre Filion; Deborah van Hagen; Bruce W. S. Robinson; Delia J. Nelson;
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1. IL-2 Intratumoral Immunotherapy Enhances CD8+ T Cells That Mediate Destruction of Tumor Cells and Tumor-Associated Vasculature: A Novel Mechanism for IL-2 [J] . Connie Jackaman, Christine S. Bundell, Beverley F. Kinnear, The journal of immunology . 2003,第10期

机译：IL-2肿瘤内免疫疗法增强介导肿瘤细胞和肿瘤相关脉管系统破坏的CD8 + T细胞：IL-2的新机制。
2. IL-2 intratumoral immunotherapy enhances CD8+ T cells that mediate destruction of tumor cells and tumor-associated vasculature: a novel mechanism for IL-2. [J] . Jackaman C, Bundell CS, Kinnear BF, The Journal of Immunology: Official Journal of the American Association of Immunologists . 2003,第10期

机译：IL-2肿瘤内免疫疗法增强CD8 + T细胞，介导肿瘤细胞和与肿瘤相关的脉管系统的破坏：IL-2的新机制。
3. Intratumoral treatment of smaller mouse neuroblastoma tumors with a recombinant protein consisting of IL-2 linked to the Hu14.18 antibody increases intratumoral CD8+ T and NK cells and improves survival [J] . YangR.K., KalogriopoulosN.A., RakhmilevichA.L., Cancer immunology, immunotherapy : . 2013,第8期

机译：用与Hu14.18抗体连接的IL-2组成的重组蛋白对较小的小鼠神经母细胞瘤进行肿瘤内治疗可增加肿瘤内CD8 + T和NK细胞并提高生存率
4. Enhanced Tumor Immunotherapy Mediated by Nanoellipsoidal Artificial Antigen Presenting Cells [C] . Randall A. Meyer, John W. Hickey, Alyssa K Kosmides, Society for Biomaterials annual meeting and exposition . 2017

机译：纳米椭球人工抗原呈递细胞介导的增强型肿瘤免疫治疗
5. Tumor-specific human primary T cells engineered to overexpress IL-2, IL-7, IL-15, or IL-21 confer varying degrees of tumor rejection and xenogeneic graft-versus-host disease in an immunodeficient mouse model. [D] . Markley, John Charles. 2009

机译：经过工程改造以过度表达IL-2，IL-7，IL-15或IL-21的肿瘤特异性人类原代T细胞可在免疫缺陷小鼠模型中赋予不同程度的肿瘤排斥反应和异种移植物抗宿主病。
6. Novel antitumor mechanism-of-action of an IL-2 fusion protein mediated by tumor associated macrophage repolarization and innate-like CD8+ memory T cells [O] . Wenxin Xu, Jack O Egan, Bai Liu, 2014

机译：肿瘤相关巨噬细胞复极化和先天样CD8 +记忆T细胞介导的IL-2融合蛋白的新型抗肿瘤作用机制
7. Novel antitumor mechanism-of-action of an IL-2 fusion protein mediated by tumor associated macrophage repolarization and innate-like CD8+ memory T cells [O] . 2014

机译：肿瘤相关巨噬细胞复极化和先天样CD8 +记忆T细胞介导的IL-2融合蛋白的新型抗肿瘤作用机制
8. Adoptive Immunotherapy for Epithelial Ovarian Cancer Using T-cells Simultaneously Targeted to Tumor and Tumor-Associated Macrophages. [R] . Maher, J., Ghaem-Maghami, S. 2013

机译：上皮性卵巢癌的过继免疫治疗使用T细胞同时针对肿瘤和肿瘤相关的巨噬细胞。

IL-2 Intratumoral Immunotherapy Enhances CD8+ T Cells That Mediate Destruction of Tumor Cells and Tumor-Associated Vasculature: A Novel Mechanism for IL-2

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