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Design, Synthesis, and Biological Evaluations of Hydroxypyridonecarboxylic Acids as Inhibitors of HIV Reverse Transcriptase Associated RNase H

机译：羟基甲基羧酸的设计，合成和生物学评价作为HIV逆转录酶相关的RNase H相关的抑制剂

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Jayakanth Kankanala; Karen A. Kirby; Feng Liu; Lena Miller; Eva Nagy; Daniel J. Wilson; Michael A. Parniak; Stefan G. Sarafianos; Zhengqiang Wang;
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1. Design, Synthesis, and Biological Evaluations of Hydroxypyridonecarboxylic Acids as Inhibitors of HIV Reverse Transcriptase Associated RNase H [J] . Kankanala Jayakanth, Kirby Karen A., Liu Feng, Journal of Medicinal Chemistry . 2016,第10期

机译：羟基吡啶酮羧酸作为HIV逆转录酶相关RNase H抑制剂的设计，合成和生物学评估。
2. Design, synthesis and biological evaluation of 3-hydroxyquinazoline-2,4(1H, 3H)-diones as dual inhibitors of HIV-1 reverse transcriptase-associated RNase H and integrase [J] . Gao Ping, Cheng Xiqiang, Sun Lin, Bioorganic and medicinal chemistry . 2019,第17期

机译：3-羟基喹唑啉-2,4（1H，3H） - 作为HIV-1逆转录酶相关的RNase H和整合酶的双重抑制剂的设计，合成和生物学评价。
3. Design, synthesis and biological evaluations of N-Hydroxy thienopyrimidine-2,4-diones as inhibitors of HIV reverse transcriptase-associated RNase H [J] . Jayakanth Kankanala, Karen A. Kirby, Andrew D. Huber, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2017,第期

机译：N-羟基噻吩嘧啶-2,4-二乙醚的设计，合成和生物学评价，作为HIV逆转录酶相关的RNase H的抑制剂
4. Evaluation of potential HIV-1 reverse transcriptase inhibitors by artificial neural networks [C] . Tetko, I.V., Tanchuk, . 1994

机译：通过人工神经网络评估潜在的HIV-1逆转录酶抑制剂
5. Design and synthesis of molecular probes to modulate cell membrane permeation: I. Design, synthesis, and biological evaluation of novel chicoric acid analogues as inhibitors of HIV-1 integrase. II. Design, synthesis, and biological evaluation of novel estradiol analogues targeting the membrane estrogen receptor. [D] . Charvat, Trevor Thomas. 2004

机译：设计和合成的分子探针，可调节细胞膜的渗透性：I.设计，合成和生物评价作为抗HIV-1整合酶抑制剂的新型菊苣酸类似物。二。针对膜雌激素受体的新型雌二醇类似物的设计，合成和生物学评估。
6. Design Synthesis and Biological Evaluations of Hydroxypyridone Carboxylic Acids as Inhibitors of HIV Reverse Transcriptase-Associated RNase H [O] . Jayakanth Kankanala, Karen A. Kirby, Feng Liu, -1

机译：设计合成和生物评价的羟基吡啶酮羧酸作为HIV逆转录酶相关的RNase H抑制剂。
7. The HIV-1 reverse transcriptase mutants G190S and G190A, which confer resistance to non-nucleoside reverse transcriptase inhibitors, demonstrate reductions in RNase H activity and DNA synthesis from tRNALys, 3 that correlate with reductions in replication efficiency [O] . J. Wang, C. Dykes, R.A. Domaoal, 2006

机译：HIV-1逆转录酶突变体G190S和G190A，其赋予非核苷逆转录酶抑制剂的抗性，证明了RNA酶H活性和从TRNARY的DNA合成的降低，3与复制效率的降低相关

Design, Synthesis, and Biological Evaluations of Hydroxypyridonecarboxylic Acids as Inhibitors of HIV Reverse Transcriptase Associated RNase H

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