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Killing two birds with one stone: Blocking the mitochondrial pyruvate carrier to inhibit lactate uptake by cancer cells and radiosensitize tumors

机译：用一块石头杀死两只鸟类：阻断线粒体丙酮酸载体抑制癌细胞和辐射敏化肿瘤的乳酸摄取

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Catherine Vander Linden; Cyril Corbet;
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年度 2018
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1. Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects [J] . Cyril Corbet, Estelle Bastien, Nihed Draoui, Nature Communications . 2018,第1期

机译：通过抑制线粒体丙酮酸的转运来中断乳酸的吸收，可以揭示直接的抗肿瘤和放射增敏作用
2. Cytotoxicity and Radiosensitizing Activity of the Fatty Acid Synthase Inhibitor C75 Is Enhanced by Blocking Fatty Acid Uptake in Prostate Cancer Cells [J] . Colin Rae, Georgios I. Fragkoulis, Anthony J. Chalmers Advances in Radiation Oncology . 2020,第5期

机译：通过阻断前列腺癌细胞中脂肪酸摄取来增强脂肪酸合酶抑制剂C75的细胞毒性和放射腺度活性。
3. The BRAF Inhibitor Vemurafenib Activates Mitochondrial Metabolism and Inhibits Hyperpolarized Pyruvate-Lactate Exchange in BRAF-Mutant Human Melanoma Cells [J] . Delgado-Goni Teresa, Miniotis Maria Falck, Wantuch Slawomir, Molecular cancer therapeutics . 2016,第12期

机译：BRAF抑制剂Vemurafenib激活线粒体代谢并抑制BRAF突变型人黑素瘤细胞中的超极化丙酮酸-乳酸交换。
4. OVEREXPRESSION OF THE MITOCHONDRIAL PYRUVATE CARRIER INCREASES CHO CELL AND RECOMBINANT PROTEIN PRODUCTIVITY AND REDUCES LACTATE PRODUCTION [C] . Dubhe B. Bulte, Carolina Gomez, Laura A. Palomares, Cell culture engineering conference . 2018

机译：线粒体丙酮酸载体的过表达增加了CHO细胞和重组蛋白的生产力，并减少了乳酸的生产
5. The identification and function of the mitochondrial pyruvate carrier: Lessons from yeast, cancer, and stem cells [D] . Schell, John Charles. 2016

机译：线粒体丙酮酸载体的鉴定和功能：酵母，癌症和干细胞的教训
6. Killing two birds with one stone: Blocking the mitochondrial pyruvate carrier to inhibit lactate uptake by cancer cells and radiosensitize tumors [O] . Catherine Vander Linden, Cyril Corbet 2018

机译：用一块石头杀死两只鸟：阻断线粒体丙酮酸载体以抑制癌细胞摄取乳酸并使肿瘤放射增敏
7. Killing two birds with one stone: BRAF V600E inhibitor therapy for hairy cell leukemia and Langerhans/dendritic cell sarcoma [O] . Vivek Subbiah, Ishwaria Mohan Subbiah 2013

机译：用一块石头杀死两只鸟：BRAF V600E抑制毛细细胞白血病和朗格汉斯/树突细胞肉瘤的抑制作用

Killing two birds with one stone: Blocking the mitochondrial pyruvate carrier to inhibit lactate uptake by cancer cells and radiosensitize tumors

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