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IMGN853, a Folate Receptor-α (FRα)–Targeting Antibody–Drug Conjugate, Exhibits Potent Targeted Antitumor Activity against FRα-Expressing Tumors

机译：IMGN853，叶酸受体-α（FRα） - 可诱导抗体 - 药物缀合物，表现出对表达FRα的肿瘤的有效的靶向抗肿瘤活性

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Olga Ab; Kathleen R. Whiteman; Laura M. Bartle; Xiuxia Sun; Rajeeva Singh; Daniel Tavares; Alyssa LaBelle; Gillian Payne; Robert J. Lutz; Jan Pinkas; Victor S. Goldmacher; Thomas Chittenden; John M. Lambert;
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1. IMGN853, a Folate Receptor-alpha (FR alpha)-Targeting Antibody-Drug Conjugate, Exhibits Potent Targeted Antitumor Activity against FR alpha-Expressing Tumors [J] . Ab Olga, Whiteman Kathleen R., Bartle Laura M., Molecular cancer therapeutics . 2015,第7期

机译：IMGN853，叶酸受体-α（FRα） - 可靶向抗体 - 药物缀合物，表现出针对FRα表达肿瘤的有效的靶向抗肿瘤活性
2. MORAb-202, an Antibody-Drug Conjugate Utilizing Humanized Anti-human FR alpha Farletuzumab and the Microtubule-targeting Agent Eribulin, has Potent Antitumor Activity [J] . Cheng Xin, Li Jing, Tanaka Keigo, Molecular cancer therapeutics . 2018,第12期

机译：Morab-202，一种利用人源化抗人类FRαFarletuzumab和微管靶向剂Eribulin的抗体 - 药物缀合物，具有有效的抗肿瘤活性
3. Characterization of folate receptor alpha (FRα) expression in archival tumor and biopsy samples from relapsed epithelial ovarian cancer patients: A phase I expansion study of the FRα-targeting antibody-drug conjugate mirvetuximab soravtansine [J] . Lainie P. Martin, Jason A. Konner, Kathleen N. Moore, Gynecologic Oncology: An International Journal . 2017,第2期

机译：复发上皮卵巢癌患者归档肿瘤和活检样品中叶酸受体α（FRα）表达的表征：FRα靶向抗体 - 药物共轭米尔韦妥昔单抗索拉斯综合症的展开研究
4. KTN0182A, an Anti-KIT, Pyrrolobenzodiazepine (PBD)-Containing Antibody Drug Conjugate (ADC) Demonstrates Potent Antitumor Activity In Vitro and In Vivo Against a Broad Range of Tumor Types [C] . Sergio Trombetta, Christine Lubeski, Gary C. Kemp, PEGS . 2015

机译：KTN0182A，抗试剂盒，吡咯唑二氮杂己酮（PBD）抗体药物缀合物（ADC）在体外和体内抗抗肿瘤类型的抗肿瘤活性
5. Development of novel folate receptor (FR)-targeted indenoisoquinoline drug delivery systems (DDSs) using acid sensitive N-Ethoxybenzylimidazole (NEBI) crosslinkers for anti-cancer therapy. [D] . Cao, Yuchen Z. 2014

机译：使用酸敏感的N-乙氧基苄基咪唑（NEBI）交联剂开发针对叶酸受体（FR）的新型腺苷异喹啉药物递送系统（DDS），用于抗癌治疗。
6. Mirvetuximab Soravtansine (IMGN853) a Folate Receptor Alpha–Targeting Antibody-Drug Conjugate Potentiates the Activity of Standard of Care Therapeutics in Ovarian Cancer Models [O] . Jose F. Ponte, Olga Ab, Leanne Lanieri, 2016

机译：Mirvetuximab Soravtansine（IMGN853）叶酸受体靶向抗体-药物结合物可增强卵巢癌模型中标准治疗药物的活性
7. MORAb-202, an Antibody–Drug Conjugate Utilizing Humanized Anti-human FRα Farletuzumab and the Microtubule-targeting Agent Eribulin, has Potent Antitumor Activity [O] . Xin Cheng, Jing Li, Keigo Tanaka, 2018

机译：Morab-202，利用人源化抗人富氏菌毒素和微管靶向剂Eribulin的抗体 - 药物缀合物具有效力抗肿瘤活性

IMGN853, a Folate Receptor-α (FRα)–Targeting Antibody–Drug Conjugate, Exhibits Potent Targeted Antitumor Activity against FRα-Expressing Tumors

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