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siRNAs containing 2′-fluorinated Northern-methanocarbacyclic (2′-F-NMC) nucleotides: in vitro and in vivo RNAi activity and inability of mitochondrial polymerases to incorporate 2′-F-NMC NTPs

机译：含有2'-氟化北方 - 甲烷碳碱（2'-F-NMC）核苷酸的siRNA：体外和体内RNAi活性和无线电细胞聚合酶不能包含2'-F-NMC NTPS

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Masaaki Akabane-Nakata; Namrata D Erande; Pawan Kumar; Rohan Degaonkar; Jason A Gilbert; June Qin; Martha Mendez; Lauren Blair Woods; Yongfeng Jiang; Maja M Janas; Derek K O’Flaherty; Ivan Zlatev; Mark K Schlegel; Shigeo Matsuda; Martin Egli; Muthiah Manoharan;
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1. Chimeric siRNAs with chemically modified pentofuranose and hexopyranose nucleotides: altritol-nucleotide (ANA) containing GalNAc-siRNA conjugates: in vitro and in vivo RNAi activity and resistance to 5 '-exonuclease [J] . Kumar Pawan, Degaonkar Rohan, Guenther Dale C., Nucleic Acids Research . 2020,第8期

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2. Chimeric siRNAs with chemically modified pentofuranose and hexopyranose nucleotides: altritol-nucleotide (ANA) containing GalNAc–siRNA conjugates: in vitro and in vivo RNAi activity and resistance to 5′-exonuclease [J] . Pawan Kumar, Rohan Degaonkar, Dale C Guenther, Nucleic acids research . 2020,第8期

机译：具有化学改性的戊脲和己糖苷核苷酸的嵌合体系：含有GalNac-siRNA缀合物的丙醇 - 核苷酸（ANA）：体外和体内RNAi活性和抗5' - 外切核酸酶
3. Antiviral Nucleotide Incorporation by Recombinant Human Mitochondrial RNA Polymerase Is Predictive of Increased In Vivo Mitochondrial Toxicity Risk [J] . Fenaux Martijn, Lin Xiaodong, Yokokawa Fumiaki, Antimicrobial agents and chemotherapy. . 2016,第12期

机译：通过重组人线粒体RNA聚合酶的抗病毒核苷酸纳入是体内线粒体毒性风险增加的预测。
4. Chimeric siRNAs with chemically modified pentofuranose and hexopyranose nucleotides: altritol-nucleotide (ANA) containing GalNAc–siRNA conjugates: in vitro and in vivo RNAi activity and resistance to 5′-exonuclease [O] . Pawan Kumar, Rohan Degaonkar, Dale C Guenther, 2020

机译：具有经过化学修饰的戊呋喃糖和六吡喃糖核苷酸的嵌合siRNA：含GalNAc-siRNA共轭物的糖醇核苷酸（ANA）：体外和体内RNAi活性和对5-核酸外切酶的抗性
5. Chimeric siRNAs with chemically modified pentofuranose and hexopyranose nucleotides: altritol-nucleotide (ANA) containing GalNAc–siRNA conjugates: in vitro and in vivo RNAi activity and resistance to 5′-exonuclease [O] . Pawan Kumar, Rohan Degaonkar, Dale C Guenther, 2020

机译：具有化学改性的戊脲和己糖苷核苷酸的嵌合体系：含有GalNac-siRNA缀合物的丙醇 - 核苷酸（ANA）：体外和体内RNAi活性和抗5' - 外切核酸酶

siRNAs containing 2′-fluorinated Northern-methanocarbacyclic (2′-F-NMC) nucleotides: in vitro and in vivo RNAi activity and inability of mitochondrial polymerases to incorporate 2′-F-NMC NTPs

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