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Discovery of a Potent Parenterally Administered Factor XIa Inhibitor with Hydroxyquinolin-2(1H)-one as the P2′ Moiety

机译：发现有效的肠外给药因子XIA抑制剂与羟基喹啉-2（1H） - 酮作为P2的部分

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Zilun Hu; Pancras C. Wong; Paul J. Gilligan; Wei Han; Kumar B. Pabbisetty; Jeffrey M. Bozarth; Earl J. Crain; Timothy Harper; Joseph M. Luettgen; Joseph E. Myers; Vidhyashankar Ramamurthy; Karen A. Rossi; Steven Sheriff; Carol A. Watson; Anzi Wei; Joanna J. Zheng; Dietmar A. Seiffert; Ruth R. Wexler; Mimi L. Quan;
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1. Discovery of a Potent Parenterally Administered Factor XIa Inhibitor with Hydroxyquinolin-2(1H)-one as the P2 ' Moiety [J] . Hu Zilun, Wong Pancras C., Gilligan Paul J., ACS medicinal chemistry letters . 2015,第5期

机译：发现强效的胃肠外给药因子XIa抑制剂与羟基喹啉-2（1H）-作为P2'部分。
2. Orally bioavailable pyridine and pyrimidine-based Factor XIa inhibitors: Discovery of the methyl N-phenyl carbamate P2 prime group [J] . Corte James R., Fang Tianan, Pinto Donald J. P., Bioorganic and medicinal chemistry . 2016,第10期

机译：口服可生物利用的基于吡啶和嘧啶的因子XIa抑制剂：N-苯基氨基甲酸酯甲基P2素基的发现
3. Potent, Orally Bioavailable, and Efficacious Macrocyclic Inhibitors of Factor XIa. Discovery of Pyridine-Based Macrocycles Possessing Phenylazole Carboxamide P1 Groups [J] . Corte James R., Pinto Donald J. P., Fang Tianan, Journal of Medicinal Chemistry . 2020,第2期

机译：有效的，口服生物可利用，和有效的巨碱基抑制剂的因子xia。发现吡啶基宏γ具有甲氨基甲酰胺P1基团
4. Design and Discovery of Diarylpyridines and Diarylanilines as Novel Potent Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors [C] . Bingjie Qin, Xingtao Tian, Xingkai Jiang, ICMSI;International conference of molecular simulations and applied informatics technologies . 2010

机译：二芳基吡啶和二芳基苯胺作为新型有效的非核苷HIV-1逆转录酶抑制剂的设计和发现
5. Characterization of a Human Immunodeficiency Virus (HIV) Type I Integrase Inhibitor-Binding Pocket and Discovery of Novel Inhibitors Potent against Drug-Resistant Variants of HIV [D] . Crosby, David Charles 2010

机译：人类免疫缺陷病毒（HIV）I型整合酶抑制剂结合口袋的表征和新型抗HIV药物耐药变体的抑制剂的发现
6. Discovery of a Potent Parenterally Administered FactorXIa Inhibitor with Hydroxyquinolin-2(1H)-oneas the P2′ Moiety [O] . Zilun Hu, *, Pancras C. Wong, 2015

机译：发现有效的胃肠外给药因素含羟基喹啉2（1H）-1的XIa抑制剂作为P2部分
7. Novel HIV-1 Protease Inhibitors (PIs) Containing a Bicyclic P2 Functional Moiety, Tetrahydropyrano-Tetrahydrofuran, That Are Potent against Multi-PI-Resistant HIV-1 Variants▿ † [O] . Ide, Kazuhiko, Aoki, Manabu, Amano, Masayuki, 2011

机译：新型的HIV-1蛋白酶抑制剂（PIs）包含具有双环P2功能部分的四氢吡喃-四氢呋喃，具有抗多重PI抗性的HIV-1变体的作用▿†

Discovery of a Potent Parenterally Administered Factor XIa Inhibitor with Hydroxyquinolin-2(1H)-one as the P2′ Moiety

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