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Effects of sterol derivatives in cationic liposomes on biodistribution and gene-knockdown in the lungs of mice systemically injected with siRNA lipoplexes

机译：甾醇衍生物在阳离子脂质体中对siRNA脂质物体注射的小鼠肺部生物分布和基因敲低的影响

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Yoshiyuki Hattori; Hiromu Saito; Teruaki Oku; Kei-Ichi Ozaki;
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1. Optimized combination of cationic lipids and neutral helper lipids in cationic liposomes for siRNA delivery into the lung by intravenous injection of siRNA lipoplexes [J] . Yoshiyuki Hattori, Kyoko Tamaki, Kei-ichi Ozaki, Journal of drug delivery science and technology . 2019,第期

机译：优化阳离子脂质和中性辅助脂质在阳离子脂质体中的组合，用于通过静脉注射siRNA脂蛋素递送到肺中的siRNA
2. Lipoplexes prepared from cationic liposomes and mammalian DNA induce CpG-independent, direct cytotoxic effects in cell cultures and in mice [J] . Khazanov E, Simberg D, Barenholz Y The journal of gene medicine . 2006,第8期

机译：由阳离子脂质体和哺乳动物DNA制备的脂质体在细胞培养物中和小鼠中诱导CpG独立的直接细胞毒性作用
3. siRNA delivery to lung-metastasized tumor by systemic injection with cationic liposomes [J] . Journal of liposome research . 2015,第4期

机译：通过全身性注射阳离子脂质体将siRNA递送至肺转移肿瘤
4. Cationic Lipoplexes for Efficient Delivery of siRNA into Retinal Pigment Epithelium Cells [C] . C.H. Chiang, C.H. Wang, C.W W. Chen Annual meeting exposition of the Controlled Release Society . 2009

机译：阳离子脂复合物可将siRNA有效传递到视网膜色素上皮细胞中
5. Self-assembly of cationic lipoplexes from liposomes and plasmids of variable size. [D] . Goncalves, Elisabete. 2003

机译：从脂质体和大小可变的质粒自组装阳离子脂质复合物。
6. Long-term Silencing of Intersectin-1s in Mouse Lungs by Repeated Delivery of a Specific siRNA via Cationic Liposomes. Evaluation of Knockdown Effects by Electron Microscopy [O] . Cristina Bardita, Dan Predescu, Sanda Predescu 2013

机译：通过阳离子脂质体重复递送特定siRNA的小鼠肺中Intersectin-1s的长期沉默。电子显微镜评估击倒效果
7. Effects of PEG anchors in PEGylated siRNA lipoplexes on in�vitro gene‑silencing effects and siRNA biodistribution in mice [O] . Yoshiyuki Hattori, Kyoko Tamaki, Sho Sakasai, 2020

机译：PEG锚杆在聚乙酰化siRNA脂肪体上的影响在�瓦氏菌属沉默效应和小鼠siRNA生物分布上的影响

Effects of sterol derivatives in cationic liposomes on biodistribution and gene-knockdown in the lungs of mice systemically injected with siRNA lipoplexes

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