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Designing Dual Inhibitors of Anaplastic Lymphoma Kinase (ALK) and Bromodomain-4 (BRD4) by Tuning Kinase Selectivity

机译：通过调节激酶选择性设计厌备淋巴瘤激酶（ALK）和溴琼瘤-4（BRD4）的双抑制剂

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Ellen Watts; David Heidenreich; Elizabeth Tucker; Monika Raab; Klaus Strebhardt; Louis Chesler; Stefan Knapp; Benjamin Bellenie; Swen Hoelder;
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年度 2019
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1. Designing Dual Inhibitors of Anaplastic Lymphoma Kinase (ALK) and Bromodomain-4 (BRD4) by Tuning Kinase Selectivity [J] . Watts Ellen, Heidenreich David, Tucker Elizabeth, Journal of Medicinal Chemistry . 2019,第5期

机译：通过调节激酶选择性设计厌备淋巴瘤激酶（ALK）和溴琼瘤-4（BRD4）的双抑制剂
2. Synthesis of deuterium-labeled crizotinib, a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK) [J] . Ao Wangwei, Li Yuan, Zhang Yinsheng Journal of Labelled Compounds and Radiopharmaceuticals . 2018,第14期

机译：合成氘标记的屈曲，间充质和间充质上皮过渡因子（C-Met）激酶和促进淋巴瘤激酶（ALK）的有效和选择性双重抑制剂
3. Structure based drug design of crizotinib (PF-02341066), a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK) [J] . Cui J.J., Tran-Dubé M., Shen H., Journal of Medicinal Chemistry . 2011,第18期

机译：克唑替尼（PF-02341066）的基于结构的药物设计，克唑替尼是一种有效的选择性间充质-上皮转化因子（c-MET）激酶和间变性淋巴瘤激酶（ALK）双重抑制剂
4. Selective tyrosine kinase inhibitor, STI571, inhibitsgrowth of p53 mutant anaplastic thyroid cancer cellsby inducing S-G2 transition arrest [C] . Alexei P. Podtcheko, Satoshi Tsuda, Akira Ohtsuru International Consortium for Medical Care of Hibakusha and Radiation Life Science . 2003

机译：选择性酪氨酸激酶抑制剂，STI571，P53突变体的抑制性诱导S-G2过渡逮捕的抑制性甲状腺癌细胞
5. Understanding the function of the JunB transcription factor in anaplastic lymphoma kinase-positive, anaplastic large cell lymphoma. [D] . Pearson, Joel Dylan. 2013

机译：了解JunB转录因子在间变性淋巴瘤激酶阳性，间变性大细胞淋巴瘤中的功能。
6. Designing DualInhibitors of Anaplastic Lymphoma Kinase(ALK) and Bromodomain-4 (BRD4) by Tuning Kinase Selectivity [O] . Ellen Watts, David Heidenreich, Elizabeth Tucker, -1

机译：设计双重间变性淋巴瘤激酶抑制剂（ALK）和Bromodomain-4（BRD4）通过调节激酶选择性
7. Designing Dual Inhibitors of Anaplastic Lymphoma Kinase (ALK) and Bromodomain4 (BRD4) by Tuning Kinase Selectivity [O] . -1

机译：通过调节激酶选择性设计促进淋巴瘤激酶（ALK）和Bromodomain4（BRD4）的双抑制剂

Designing Dual Inhibitors of Anaplastic Lymphoma Kinase (ALK) and Bromodomain-4 (BRD4) by Tuning Kinase Selectivity

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