首页> 外文OA文献 >Discovery and Characterization of R/S-N-3-Cyanophenyl-N-(6-tert-butoxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)urea, a New Histone Deacetylase Class III Inhibitor Exerting Antiproliferative Activity against Cancer Cell Lines

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Discovery and Characterization of R/S-N-3-Cyanophenyl-N-(6-tert-butoxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)urea, a New Histone Deacetylase Class III Inhibitor Exerting Antiproliferative Activity against Cancer Cell Lines

机译：r / sn-3-氰基聚苯基-n-（6-叔丁氧基羰基氨基-3,4-二氢-2,2-二甲基-2h-1-苯并吡喃-4-基-2h-1-苯并吡喃-4-基）尿素的发现和表征，一种新的组蛋白脱乙酰酶类III抑制剂对癌细胞系施加抗增殖活性

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1. Discovery and Characterization of R/S-N-3-Cyanophenyl-N '-(6-tert-butoxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)urea, a New Histone Deacetylase Class III Inhibitor Exerting Antiproliferative Activity against Cancer Cell Lines [J] . Schnekenburger Michael, Goffin Eric, Lee Jin-Young, Journal of Medicinal Chemistry . 2017,第11期

机译：r / sn-3-氰基苯基-n' - （6-叔丁氧基羰基氨基-3,4-二氢-2,2-二甲基-2h-1-苯并吡喃-4-基）尿素，一种新的组蛋白脱乙酰酶的发现和表征 III类抑制剂对癌细胞系施加抗增殖活性
2. Valproic acid, an anti-epileptic drug and a histone deacetylase inhibitor, in combination with proteasome inhibitors exerts antiproliferative, pro-apoptotic and chemosensitizing effects in human colorectal cancer cells: Underlying molecular mechanisms [J] . Abaza Mohamed-Salah I., Bahman Abdul-Majeed, Al-Attiyah Rajaa J. International journal of molecular medicine . 2014,第2期

机译：丙戊酸，一种抗癫痫药和一种组蛋白脱乙酰基酶抑制剂，与蛋白酶体抑制剂联合使用，可在人大肠癌细胞中发挥抗增殖，促凋亡和化学增敏作用：潜在的分子机制
3. Valproic acid, an anti-epileptic drug and a histone deacetylase inhibitor, in combination with proteasome inhibitors exerts antiproliferative, pro-apoptotic and chemosensitizing effects in human colorectal cancer cells: Underlying molecular mechanisms [J] . AbazaMohamed-Salah I., BahmanAbdul-Majeed, Al-AttiyahRaja#39, International journal of molecular medicine . 2014,第2期

机译：与蛋白酶体抑制剂组合的丙戊酸，抗癫痫药物和组蛋白脱乙酰酶抑制剂在人结肠直肠癌细胞中施加抗增殖，促细胞凋亡和化学溶解作用：潜在的分子机制
4. A bridge between natural products to cancer drugs:Toward subclass selective cyclic-peptide-inhibitors of histone deacetylases [C] . Norikazu Nishino, Binoy Jose, Tamaki Kato International Peptide Symposium;European Peptide Symposium . 2005

机译：天然产物与癌症药物之间的桥梁：朝向组蛋白脱乙酰酶的亚类选择性环肽抑制剂
5. P27 as a molecular target for cancer therapeutics: Discovering small molecule inhibitors of p27 proteolysis and structure-activity relationship and mechanistic studies of largazole, a potent inhibitor of histone deacetylase . [D] . Ungermannova, Dana. 2010

机译：P27作为癌症治疗的分子靶标：发现p27蛋白水解和结构活性关系的小分子抑制剂以及组蛋白脱乙酰基酶的有效抑制剂largazole的机理研究。
6. Synergistic activity of the histone deacetylase inhibitor trichostatin A and the proteasome inhibitor PS-341 against taxane-resistant ovarian cancer cell lines [O] . Xin Jin, Yong Fang, Yi Hu, -1

机译：组蛋白脱乙酰基酶抑制剂曲古抑菌素A和蛋白酶体抑制剂PS-341对紫杉烷耐药性卵巢癌细胞系的协同活性
7. Discovery and Characterization of R/S-N-3-Cyanophenyl-N'-(6-tert-butoxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)urea, a New Histone Deacetylase Class III Inhibitor Exerting Antiproliferative Activity against Cancer Cell Lines [O] . Schnekenburger, M, Goffin, Eric, Lee, J-Y, 2017

机译：一种新型组蛋白脱乙酰基酶R / SN-3-氰基苯基-N'-（6-叔丁氧基羰基氨基-3,4-二氢-2,2-二甲基-2H-1-苯并吡喃-4-基）脲的发现与表征对癌细胞系具有抗增殖活性的III类抑制剂

Discovery and Characterization of R/S-N-3-Cyanophenyl-N-(6-tert-butoxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)urea, a New Histone Deacetylase Class III Inhibitor Exerting Antiproliferative Activity against Cancer Cell Lines

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