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Identification of Phe313 of the Gonadotropin-Releasing Hormone (GnRH) Receptor as a Site Critical for the Binding of Nonpeptide GnRH Antagonists

机译：促进促性腺激素释放激素（GnRH）受体的PHE313作为对非肽GNRH拮抗剂结合的担忧

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1. Synthesis and in vitro evaluation of small-molecule [18F] labeled gonadotropin-releasing hormone (GnRH) receptor antagonists as potential PET imaging agents for GnRH receptor expression [J] . OlbergD.E., AndressenK.W., LevyF.O., Bioorganic and Medicinal Chemistry Letters . 2014,第7期

机译：小分子的合成和体外评价[18F]标记的促性腺激素 - 释放激素（GnRH）受体拮抗剂作为GnRH受体表达的潜在PET成像剂
2. Synthesis and in vitro evaluation of small-molecule [18F] labeled gonadotropin-releasing hormone (GnRH) receptor antagonists as potential PET imaging agents for GnRH receptor expression [J] . OlbergD.E., AndressenK.W., LevyF.O., Bioorganic and Medicinal Chemistry Letters . 2014,第7期

机译：小分子[18F]标记的促性腺激素释放激素（GnRH）受体拮抗剂的合成及其体外评价，可作为表达GnRH受体的潜在PET成像剂
3. Changes to gonadotropin-releasing hormone (GnRH) receptor extracellular loops differentially affect GnRH analog binding and activation: evidence for distinct ligand-stabilized receptor conformations. [J] . Pfleger KD, Pawson AJ, Millar RP Endocrinology . 2008,第6期

机译：促性腺激素释放激素（GnRH）受体胞外环的变化差异地影响GnRH类似物的结合和激活：独特的配体稳定受体构象的证据。
4. Novel GnRH Antagonists Derived from Degarelix: Exploration of the GnRH Antagonist Pharmacophore [C] . Manoj P. Samant, Doley J. Hong, Glenn Croston American Peptide Symposium . 2006

机译：来自Degarelix的新型GnRH拮抗剂：探索Gnrh拮抗剂药程
5. Melatonin-mediated regulation of gonadotropin-releasing hormone (GnRH): Role of melatonin receptors and circadian rhythms. [D] . Gillespie, Julia Margaret Amy. 2002

机译：褪黑激素介导的促性腺激素释放激素（GnRH）的调节：褪黑激素受体和昼夜节律的作用。
6. Graded Inhibition of Pulsatile Luteinizing Hormone Secretion by a Selective Gonadotropin-Releasing Hormone (GnRH)-Receptor Antagonist in Healthy Men: Evidence That Age Attenuates Hypothalamic GnRH Outflow [O] . Paul Y. Takahashi, Peter Y. Liu, Pamela D. Roebuck, -1

机译：选择性促性腺激素释放激素（GnRH）-受体拮抗剂在健康男性中对促性黄体激素分泌的分级抑制：年龄减弱下丘脑GnRH流出的证据。
7. Homologous Desensitization of Gonadotropin-Releasing Hormone (GnRH) Receptors in the Goldfish Pituitary: Effects of Native GnRH Peptides and a Synthetic GnRH Antagonist1 [O] . Hamid R. Habibi 1991

机译：金鱼垂体中促性腺激素释放激素（GNRH）受体的同源脱敏：天然GnRH肽和合成GnRH拮抗剂的影响
8. Estradiol Alters the Effectiveness of Gonadotropin-Releasing Hormone (GnRH) in Ovine Pituitary Cultures: GnRH Receptors versus Responsiveness to GnRH [R] . Laws, S. C., Webster, J. C., Miller, W. L. 1990

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Identification of Phe313 of the Gonadotropin-Releasing Hormone (GnRH) Receptor as a Site Critical for the Binding of Nonpeptide GnRH Antagonists

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