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YM753, a novel histone deacetylase inhibitor, exhibits antitumor activity with selective, sustained accumulation of acetylated histones in tumors in the WiDr xenograft model

机译：一种新型组蛋白脱乙酰化酶抑制剂，具有选择性的，在WIDR异种移植模型中的肿瘤中具有选择性，持续积累的抗肿瘤活性，其具有选择性的，持续的乙酰化组蛋白

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Nobuaki Shindoh; Masamichi Mori; Yoh Terada; Kazuo Oda; Nobuaki Amino; Aya Kita; Masatoshi Taniguchi; Kin-Ya Sohda; Koji Nagai; Yoshihiro Sowa; Yuhta Masuoka; Masaya Orita; Masao Sasamata; Hitoshi Matsushime; Kiyoshi Furuichi; Toshiyuki Sakai;
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1. YM753, a novel histone deacetylase inhibitor, exhibits antitumor activity with selective, sustained accumulation of acetylated histones in tumors in the WiDr xenograft model [J] . Nobuaki Shindoh, Masamichi Mori, Yoh Terada, International journal of oncology . 2008,第3期

机译：YM753是一种新型的组蛋白脱乙酰基酶抑制剂，在WiDr异种移植模型中表现出抗肿瘤活性，并在肿瘤中选择性，持续积累乙酰化组蛋白。
2. Histone deacetylase inhibitors with a primary amide zinc binding group display antitumor activity in xenograft model. [J] . Attenni B, Ontoria JM, Cruz JC Bioorganic and Medicinal Chemistry Letters . 2009,第11期

机译：具有伯酰胺锌结合基团的组蛋白脱乙酰酶抑制剂在异种移植模型中显示抗肿瘤活性。
3. Sustained inhibition of deacetylases is required for the antitumor activity of the histone deactylase inhibitors panobinostat and vorinostat in models of colorectal cancer [J] . WilsonP.M., LabonteM.J., MartinS.C., Investigational new drugs. . 2013,第4期

机译：对于组蛋白去乙酰化酶抑制剂panobinostat和vorinostat在结直肠癌模型中的抗肿瘤活性，必须持续抑制脱乙酰基酶
4. THE NOVEL HDAC INHIBITOR HDAC-42 EXHIBITS BIOLOGIC ACTIVITY AGAINST MALIGNANT MAST CELL TUMORS THROUGH BOTH KIT AND HISTONE DEPENDENT PATHWAYS [C] . Tzu-Yin Lin, Sridhar Murahari, Sam Kulp, Annual Conference of the Veterinary Cancer Society . 2009

机译：新型HDAC抑制剂HDAC-42通过试剂盒和组蛋白依赖性途径对恶性肥大细胞肿瘤进行生物活性
5. The Synthetic Oleanane Triterpenoids and the Histone Deacetylase Inhibitor Vorinostat Cooperate to Delay Tumor Development in a Transgenic Model of Estrogen Receptor -- Negative Breast Cancer. [D] . Tran, Kim M. 2012

机译：合成的齐墩果烷三萜类化合物和组蛋白脱乙酰基酶抑制剂伏立诺他合用以延迟雌激素受体-阴性乳腺癌转基因模型中的肿瘤发展。
6. The novel histone deacetylase inhibitor N-hydroxy-7-(2-naphthylthio) hepatonomide exhibits potent antitumor activity due to cytochrome-c-release-mediated apoptosis in renal cell carcinoma cells [O] . Ki Cheong Park, Jun Hyeok Heo, Jeong Yong Jeon, 2015

机译：新型组蛋白脱乙酰基酶抑制剂N-羟基-7-（2-萘硫基）肝素由于细胞色素C释放介导的肾细胞癌细胞凋亡显示出强大的抗肿瘤活性
7. Novel histone deacetylase inhibitor AR-42 exhibits antitumor activity in pancreatic cancer cells by affecting multiple biochemical pathways. [O] . Yi-Jin Chen, Wen-Hung Wang, Wan-Yu Wu, 2017

机译：新型组蛋白去乙酰化酶抑制剂aR-42通过影响多种生化途径在胰腺癌细胞中表现出抗肿瘤活性。

YM753, a novel histone deacetylase inhibitor, exhibits antitumor activity with selective, sustained accumulation of acetylated histones in tumors in the WiDr xenograft model

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