首页> 外文OA文献 >IgG anti-hinge antibodies against IgG4 F(ab’)2 fragments generated using pepsin are useful diagnostic markers for rheumatoid arthritis: implications of the possible roles of metalloproteinases and IgG subclasses in generating immunogenic hinge epitopes

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IgG anti-hinge antibodies against IgG4 F(ab’)2 fragments generated using pepsin are useful diagnostic markers for rheumatoid arthritis: implications of the possible roles of metalloproteinases and IgG subclasses in generating immunogenic hinge epitopes

机译：IgG抗铰链针对IgG4 F（AB'）的抗铰链抗体使用胃蛋白酶产生的2个片段是类风湿性关节炎的有用诊断标志物：金属蛋白酶和IgG亚类在产生免疫原性铰链表位时可能作用的影响

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Toshiyuki Ota; Shun-ichiro Ota; Ayumi Uchino; Shuji Nagano;
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1. IgG anti-hinge antibodies against IgG4 F(ab’) 2 fragments generated using pepsin are useful diagnostic markers for rheumatoid arthritis: implications of the possible roles of metalloproteinases and IgG subclasses in generating immunogenic hinge epitopes [J] . Toshiyuki Ota, Shun-ichiro Ota, Ayumi Uchino, Arthritis research & therapy. . 2020,第1期

机译：IgG抗铰链针对IgG4 F（AB'）的抗铰链抗体使用胃蛋白酶产生的2个片段是类风湿性关节炎的有用诊断标志物：金属蛋白酶和IgG亚类在产生免疫原性铰链表位时可能作用的影响
2. Half molecular exchange of IgGs in the blood of healthy humans: chimeric lambda-kappa-immunoglobulins containing HL fragments of antibodies of different subclasses (IgG1-IgG4) [J] . Sergey E. Sedykh, Evgenii A. Lekchnov, Viktor V. Prince, Molecular BioSystems . 2016,第10期

机译：健康人血液中IgG的半分子交换：包含不同亚类抗体HL片段的嵌合lambda-κ-免疫球蛋白（IgG1-IgG4）
3. Antibodies to IgG4 Hinge Can Be Found in Rheumatoid Arthritis Patients During All Stages of Disease and May Exacerbate Chronic Antibody-Mediated Inflammation [J] . Lotte A. van de Stadt, Henk de Vrieze, Ninotska I. L. Derksen, Arthritis and Rheumatism . 2014,第5期

机译：在类风湿性关节炎患者的所有疾病阶段都可能发现IgG4铰链抗体，并且可能加剧慢性抗体介导的炎症
4. Immunoglobulin (Ig)G1 and IgG4 anti‐cyclic citrullinated peptide (CCP) associate with shared epitope whereas IgG2 anti‐CCP associates with smoking in patients with recent‐onset rheumatoid arthritis (the Swedish TIRA project) [O] . K. Martinsson, A. Johansson, A. Kastbom, 2017

机译：免疫球蛋白（Ig）G1和IgG4抗环瓜氨酸肽（CCP）与共有表位相关而IgG2抗CCP与最近发作的类风湿关节炎患者吸烟相关（瑞典TIRA项目）
5. IgG anti-hinge antibody against IgG4 F(ab’)2 generated by not matrix metalloproteinase-3 but pepsin is a useful diagnostic marker for rheumatoid arthritis, even seronegative rheumatoid arthritis. [O] . Toshiyuki Ota, Shun-ichiro Ota, Ayumi Uchino, 2020

机译：IgG抗铰链抗体对非基质金属蛋白酶-3产生的IgG4 F（AB'）2，但百辛是类风湿性关节炎的有用诊断标志物，甚至是血清腺性类风湿性关节炎。

IgG anti-hinge antibodies against IgG4 F(ab’)2 fragments generated using pepsin are useful diagnostic markers for rheumatoid arthritis: implications of the possible roles of metalloproteinases and IgG subclasses in generating immunogenic hinge epitopes

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