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High glucose and insulin in combination cause insulin receptor substrate-1 and -2 depletion and protein kinase B desensitisation in primary cultured rat adipocytes: possible implications for insulin resistance in type 2 diabetes

机译：高葡萄糖和胰岛素组合引起胰岛素受体底物-1和-2馏分和蛋白激酶B在原代培养大鼠脂肪细胞中的脱盐：可能对2型糖尿病患者胰岛素抵抗的影响

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J Buren; HX Liu; J Lauritz; JW Eriksson;
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1. Combined use of insulin and endothelin-1 causes decrease of protein expression of beta-subunit of insulin receptor, insulin receptor substrate-1, and insulin-stimulated glucose uptake in rat adipocytes. [J] . Shih KC, Kwok CF, Ho LT Journal of cellular biochemistry. . 2000,第2期

机译：胰岛素和内皮素-1的联合使用会导致大鼠脂肪细胞中胰岛素受体β亚基，胰岛素受体底物1和胰岛素刺激的葡萄糖摄取的蛋白质表达下降。
2. Insulin resistance induced by high glucose and high insulin precedes insulin receptor substrate 1 protein depletion in human adipocytes. [J] . Renstrom F, Buren J, Svensson M, Metabolism: Clinical and Experimental . 2007,第2期

机译：在人脂肪细胞中，高葡萄糖和高胰岛素诱导的胰岛素抵抗先于胰岛素受体底物1蛋白消耗。
3. Rescuing 3T3-L1 adipocytes from insulin resistance induced by stimulation of Akt-mammalian target of rapamycin/p70 S6 kinase (S6K1) pathway and serine phosphorylation of insulin receptor substrate-1: effect of reduced expression of p85alpha subunit o [J] . Adochio R, Leitner JW, Hedlund R, Endocrinology . 2009,第3期

机译：通过刺激雷帕霉素/ p70s6激酶（S6K1）途径（S6K1）途径刺激诱导的胰岛素抵抗诱导的3T3-L1脂肪细胞，胰岛素受体基质的丝氨酸磷酸化-1：降低P85Alpha亚基表达的影响
4. The Fluctuation of Blood Glucose, Insulin and Glucagon Concentrations Before and After Insulin Therapy in Type 1 Diabetes [C] . Idam Arif, Zulfa Nasir International Conference on Mathematics and Natural Sciences . 2015

机译：胰岛素治疗前后血糖，胰岛素和胰高血糖素浓度在1型糖尿病中的波动
5. Evaluating Hypoglycemic Risk of Two Basal Insulin Delivery Methods for Type 1 Diabetes: A Comparison of Tresiba Insulin Against Continuous Subcutaneous Insulin Infusion Using Data from Continuous Glucose Monitors [D] . Lane, Benjamin. 2020

机译：评估1型糖尿病两种基础胰岛素递送方法的低血糖风险：使用来自连续葡萄糖监测器的数据进行TRESIBA胰岛素对连续皮下胰岛素输注的比较
6. Contraction inhibits insulin-stimulated insulin receptor substrate-1/2-associated phosphoinositide 3-kinase activity but not protein kinase B activation or glucose uptake in rat muscle. [O] . J P Whitehead, M A Soos, R Aslesen, 2000

机译：收缩抑制大鼠肌肉中胰岛素刺激的胰岛素受体底物1/2相关的磷酸肌醇3激酶活性但不抑制蛋白激酶B激活或葡萄糖摄取。
7. Dexamethasone impairs insulin signalling and glucose transport by depletion of insulin receptor substrate-1, phosphatidylinositol 3-kinase and protein kinase B in primary cultured rat adipocytes [O] . J Buren, HX Liu, J Jensen, 2002

机译：地塞米松通过在原代培养的大鼠脂肪细胞中耗尽胰岛素受体基质-1，磷脂酰肌醇3-激酶和蛋白激酶B，通过耗尽胰岛素信号和葡萄糖传输

High glucose and insulin in combination cause insulin receptor substrate-1 and -2 depletion and protein kinase B desensitisation in primary cultured rat adipocytes: possible implications for insulin resistance in type 2 diabetes

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