Environmental exposure to non-persistent endocrine disrupting chemicals and semen quality: An overview of the current epidemiological evidence

摘要

Some of the recent publications have reported a decline in semen quality in the last few decades. This phenomenon is associatedwith environmental factors, particularly with exposure to endocrine disrupting chemicals (EDCs). The aim of this publicationis to critically review the literature on exposure to the following 6 ubiquitous environmental non-persistent EDCs:bisphenol A, triclosan, parabens, synthetic pyrethroids, organophosphate pesticides and phthalates, and on their influenceon semen quality measured as sperm concentration, sperm volume, total sperm count, motility, total motile count, morphology,sperm motion, sperm DNA damage (comet extent, tail length, tail distributed moment, percent of DNA located inthe tail (tail%), DNA fragmentation index, high DNA stainability, X:Y ratio and aneuploidy. Several electronic databaseswere systematically searched until 31 August 2016. Studies were qualified for the review if they: linked environmental exposureto non-persistent EDCs to semen quality outcomes, were published in English after 2006 (and, in the case of phthalates,if they were published after 2009) and were conducted in the case of humans. Out of the 970 references, 45 articleswere included in the review. This review adds to the body of evidence that exposure to non-persistent EDCs may affectsemen quality parameters and decrease semen quality. Int J Occup Med Environ Health 2018;31(4):377–414