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Screening of a low affinity fragment library using protein crystallography: Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of pp60Src are identicall to those for high affinity binding of full length in

机译：使用蛋白质晶体筛选低亲和力片段文库：对PP60SRC的SH 2结构域的低亲和力抑制剂片段的特异性结合的要求是具有全长的高亲和力结合的亚峰值

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1. Requirements for Specific Binding of Low Affinity Inhibitor Fragments to the SH2 Domain of ~(pp60)Src Are Identical to Those for High Affinity Binding of Full Length Inhibitors [J] . Gudrun Lange, Dominique Lesuisse, Pierre Deprez, Journal of Medicinal Chemistry . 2003,第24期

机译：低亲和力抑制剂片段与〜（pp60）Src SH2域的特异性结合的要求与全长抑制剂的高亲和力结合的要求相同
2. Fragment length influences affinity for Cu2+ and Ni2+ binding to His96 or His111 of the prion protein and spectroscopic evidence for a multiple histidine binding only at low pH [J] . John?H. Viles, Mark Klewpatinond The biochemical journal . 2007,第3期

机译：片段长度影响对Cu2 +和Ni2 +结合病毒蛋白的His96或His111的亲和力，并且光谱证据表明只有在低pH下才能有多个组氨酸结合
3. Fragment length influences affinity for Cu2+ and Ni2+ binding to His(96) or His(111) of the prion protein and spectroscopic evidence for a multiple histidine binding only at low pH [J] . Klewpatinond M, Viles JH The Biochemical Journal . 2007,第3期

机译：片段长度影响Cu2 +和Ni2 +与to病毒蛋白的His（96）或His（111）结合的亲和力，并且光谱证据表明仅在低pH下才有多个组氨酸结合
4. Shark Attack: High Affinity Binding Proteins Derived from Shark vNAR Domains by Stepwise In Vitro Affinity Maturation [C] . Stefan Zielonka PEGS . 2014

机译：鲨鱼攻击：高亲和力结合蛋白通过逐步的体外亲和力成熟衍生自Shark VNAR结构域
5. Binding Affinity and Specificity of SH2 Domain Interactions in Receptor Tyrosine Kinase Signaling Networks [D] . Ronan, Thomas James, III. 2017

机译：受体酪氨酸激酶信号网络中的SH2域相互作用的结合亲和力和特异性。
6. Fragment length influences affinity for Cu2+ and Ni2+ binding to His96 or His111 of the prion protein and spectroscopic evidence for a multiple histidine binding only at low pH [O] . Mark Klewpatinond, John H. Viles 2007

机译：片段长度影响对Cu2 +和Ni2 +结合ion病毒蛋白的His96或His111的亲和力并且光谱证据表明只有在低pH下才能结合多个组氨酸
7. Fragment length influences affinity for Cu2+ and Ni2+ binding to His96 or His111 of the prion protein and spectroscopic evidence for a multiple histidine binding only at low pH [O] . Klewpatinond, Mark, Viles, John H. 2007

机译：片段长度影响对Cu2 +和Ni2 +结合ion病毒蛋白的His96或His111的亲和力，并且光谱证据表明只有在低pH下才能结合多个组氨酸
8. Short-Term Desensitization of Muscarinic Cholinergic Receptors in Mouse Neuroblastoma Cells: Selective Loss of Agonist Low-Affinity and Pirenzepine High-Affinity Binding Sites [R] . Cioffi, C. L., El-Fakahany, E. E. 1986

机译：小鼠神经母细胞瘤细胞中毒蕈碱胆碱能受体的短期脱敏：激动剂低亲和力和哌仑西平高亲和力结合位点的选择性丧失

Screening of a low affinity fragment library using protein crystallography: Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of pp60Src are identicall to those for high affinity binding of full length in

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