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Examination of Diazaspiro Cores as Piperazine Bioisosteres in the Olaparib Framework Shows Reduced DNA Damage and Cytotoxicity

机译：在Olaparib框架中作为哌嗪生物蛋白剂的Diazaspiro核心检查显示DNA损伤和细胞毒性降低

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Sean W. Reilly; Laura N. Puentes; Khadija Wilson; Chia-Ju Hsieh; Chi-Chang Weng; Mehran Makvandi; Robert H. Mach;
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1. Examination of Diazaspiro Cores as Piperazine Bioisosteres in the Olaparib Framework Shows Reduced DNA Damage and Cytotoxicity [J] . Reilly Sean W., Puentes Laura N., Wilson Khadija, Journal of Medicinal Chemistry . 2018,第12期

机译：在Olaparib框架中作为哌嗪生物蛋白剂的Diazaspiro核心检查显示DNA损伤和细胞毒性降低
2. The Use of Olaparib (AZD2281) Potentiates SN-38 Cytotoxicity in Colon Cancer Cells by Indirect Inhibition of Rad51-Mediated Repair of DNA Double-Strand Breaks [J] . Tahara Makiko, Inoue Takeshi, Sato Futoshi, Molecular cancer therapeutics . 2014,第5期

机译：Olaparib（AZD2281）的使用通过间接抑制Rad51介导的DNA双链断裂修复来增强结肠癌细胞中的SN-38细胞毒性。
3. The Use of Olaparib (AZD2281) Potentiates SN-38 Cytotoxicity in Colon Cancer Cells by Indirect Inhibition of Rad51-Mediated Repair of DNA Double-Strand Breaks [J] . Tahara Makiko, Inoue Takeshi, Sato Futoshi, Molecular cancer therapeutics . 2014,第5期

机译：使用olaparib（azd2281）通过间接抑制rad51介导的DNA双链修复来调节结肠癌细胞中的SN-38细胞毒性
4. Aflatoxin B1 and aflatoxin M1 induced cytotoxicity and DNA damage in differentiated and undifferentiated Caco-2 cells [C] . J.Zhang, N.Zheng, S.L.Li, 4th international symposium on dairy cow nutrition and milk quality proceedings . 2015

机译：黄曲霉毒素B1和黄曲霉毒素M1诱导分化和未分化的Caco-2细胞的细胞毒性和DNA损伤
5. Cytotoxicity of reducible polycations and subcellular trafficking of their DNA nanoparticles [D] . Huang, Yi 2007

机译：可还原聚阳离子的细胞毒性及其DNA纳米粒子的亚细胞运输
6. Examination of Diazaspiro Cores as Piperazine Bioisosteres in the Olaparib Framework Shows Reduced DNA Damage and Cytotoxicity [O] . Sean W. Reilly, Laura N. Puentes, Khadija Wilson, -1

机译：检查Diazaspiro核心作为Olaparib框架中的哌嗪生物等排剂显示减少的DNA损伤和细胞毒性
7. Escherichia coliFPG and human OGG1 reduce DNA damage and cytotoxicity by BCNU in human lung cells [O] . Ying-Hui He, Yi Xu, Masayoshi Kobune, 2002

机译：大肠杆菌和人OGG1通过BCNU在人肺细胞中降低DNA损伤和细胞毒性

Examination of Diazaspiro Cores as Piperazine Bioisosteres in the Olaparib Framework Shows Reduced DNA Damage and Cytotoxicity

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