首页> 外文OA文献 >Optimization of Subsite Binding to the b5 Subunit of the Human 20S Proteasome Using Vinyl Sulfones and 2-Keto-1, 3, 4-oxadiazoles: Syntheses and Cellular Properties of Potent, Selective Proteasome Inhibitors

【2h】

Optimization of Subsite Binding to the b5 Subunit of the Human 20S Proteasome Using Vinyl Sulfones and 2-Keto-1, 3, 4-oxadiazoles: Syntheses and Cellular Properties of Potent, Selective Proteasome Inhibitors

机译：使用乙烯基砜和2-酮-1,3,4-二氧化氮的液位结合对人20S蛋白酶体B5亚基的底座结合：合成和有效的选择性蛋白酶体抑制剂的合成和细胞性能

代理获取

本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。

页面导航

著录项
相似文献
相关主题

著录项

作者

展开▼
作者单位

展开▼
年度 -1
总页数
原文格式 PDF
正文语种
中图分类

相似文献

外文文献

1. Optimization of subsite binding to the beta 5 subunit of the human 20S proteasome using vinyl sulfones and 2-keto-1,3,4-oxadiazoles: Syntheses and cellular properties of potent, selective proteasome inhibitors [J] . Rydzewski RM, Burrill L, Mendonca R, Journal of Medicinal Chemistry . 2006,第10期

机译：使用乙烯基砜和2-酮-1,3,4-恶二唑优化与人20S蛋白酶体β5亚基结合的亚位点：有效的选择性蛋白酶体抑制剂的合成和细胞特性
2. Cereblon inhibits proteasome activity by binding to the 20S core proteasome subunit beta type 4 [J] . LeeK.M., LeeJ., ParkC.-S. Biochemical and Biophysical Research Communications . 2012,第3期

机译：通过结合20s核心蛋白酶体亚基β型，酰胺抑制蛋白酶体活性
3. Novel beta-lactam derivatives: potent and selective inhibitors of the chymotrypsin-like activity of the human 20S proteasome. [J] . Imbach P, Lang M, Garcia-Echeverria C, Bioorganic and Medicinal Chemistry Letters . 2007,第2期

机译：新型β-内酰胺衍生物：人20S蛋白酶体类胰凝乳蛋白酶样活性的有效和选择性抑制剂。
4. Part I. Design of a novel class of reversible non-covalent small molecule inhibitors for human Granzyme B (hBrB) Part II. Curcumin and mimics as proteasome inhibitors Part III. Design of novel coactivator binding inhibitors (CBIs) for the estrogen receptor alpha: Break the 1muM barrier. [D] . Kim, Mi-Sun. 2012

机译：第一部分。设计用于人类颗粒酶B（hBrB）的新型可逆非共价小分子抑制剂。第二部分。姜黄素和模拟物作为蛋白酶体抑制剂第三部分。新型的针对雌激素受体α的共激活因子结合抑制剂（CBI）的设计：打破1μM的障碍。
5. Discovery of a potent and highly β1 specific proteasome inhibitor from a focused library of urea-containing peptide vinyl sulfones and peptide epoxyketones [O] . Wouter A. van der Linden, Lianne I. Willems, Tamer B. Shabaneh, -1

机译：从含尿素肽乙烯基砜的聚焦库中的有效且高度β1特异性蛋白酶体抑制剂的发现和肽环氧酮
6. Cells adapted to the proteasome inhibitor 4-hydroxy- 5-iodo-3-nitrophenylacetyl-Leu-Leu-leucinal-vinyl sulfone require enzymatically active proteasomes for continued survival [O] . Princiotta, Michael F., Schubert, Ulrich, Chen, Weisan, 2001

机译：适应蛋白酶体抑制剂的细胞 4-羟基-5-碘-3-硝基苯基乙酰-Leu-Leu-亮氨酸-乙烯基砜需要酶活性蛋白酶体才能持续生存

Optimization of Subsite Binding to the b5 Subunit of the Human 20S Proteasome Using Vinyl Sulfones and 2-Keto-1, 3, 4-oxadiazoles: Syntheses and Cellular Properties of Potent, Selective Proteasome Inhibitors

著录项

相似文献

相关主题

期刊订阅