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Inhibitors of Phenylethanolamine N-Methyltransferase That Are Predicted To Penetrate the Blood-Brain Barrier: Design, Synthesis, and Evaluation of 3-Fluoromethyl-7-(N-substituted aminosulfonyl)-1, 2, 3, 4-tetrahydroisoquinolines That Possess Low Affinity toward the a2-Adrenoceptor

机译：预测苯乙醇胺N-甲基转移酶的抑制剂，其预测渗透血脑屏障：3-氟甲基-7-（n-取代的氨基磺酰基）-1,2,3，4-四羟异喹啉的设计，合成和评价，具有低亲和力朝着A2-adrenceptorver

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1. Inhibitors of Phenylethanolamine N-Methyltransferase That Are Predicted To Penetrate the Blood-Brain Barrier: Design, Synthesis, and Evaluation of 3-Fluoromethyl-7-(N-substituted aminosulfonyl)-1,2,3,4-tetrahydroisoquinolines That Possess Low Affinit [J] . Romero FA, Vodonick SM, Criscione KR, Journal of Medicinal Chemistry . 2004,第18期

机译：预计会穿透血脑屏障的苯乙醇胺N-甲基转移酶抑制剂：具有低亲和力的3-氟甲基-7-（N-取代的氨基磺酰基）-1,2,3,4-四氢异喹啉的设计，合成和评估
2. Nanomolar inhibitors of CNS epinephrine biosynthesis: (R)-(+)-3-fluoromethyl-7-(N-substituted aminosulfonyl)-1,2,3,4-tetrahydroisoquinolines as potent and highly selective inhibitors of phenylethanolamine N-methyltransferase1. [J] . Grunewald GL, Romero FA, Criscione KR Journal of Medicinal Chemistry . 2005,第6期

机译：CNS肾上腺素生物合成的纳摩尔抑制剂：（R）-（+）-3-氟甲基-7-（N-取代的氨基磺酰基）-1,2,3,4-四氢异喹啉作为苯基乙醇胺N-甲基转移酶的有效抑制剂和高度选择性抑制剂。
3. 3-Hydroxymethyl-7-(N-substituted aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline inhibitors of phenylethanolamine N-methyltransferase that display remarkable potency and selectivity [J] . Grunewald GL, Romero FA, Criscione KR Journal of Medicinal Chemistry . 2005,第1期

机译：苯乙醇胺N-甲基转移酶的3-羟甲基-7-（N-取代的氨基磺酰基）-1,2,3,4-四氢异喹啉抑制剂显示出显着的效能和选择性
4. Evolutionary combinatorial chemistry:a novel tool for SAR studies on peptide transport across the blood-brain barrier 2.Design,synthesis and evaluation of the first peptide generation [C] . Meritxell Teixido, Ignasi Belda, Sonia Gonzalez International Peptide Symposium;European Peptide Symposium . 2005

机译：进化组合化学：一种新型工具，用于血脑屏障肽输送的SAR研究2.第一肽生成的设计，合成和评价
5. Design Synthesis and In Vitro Evaluation of Potential West Nile Virus Protease Inhibitors Based on the 1-Oxo-1 2 3 4-tetrahydroisoquinoline and 1-Oxo-1 2-dihydroisoquinoline Scaffolds [O] . Dengfeng Dou, Prasanth Viwanathan, Yi Li, -1

机译：设计合成和潜在的西尼罗河病毒蛋白酶抑制剂基于对1-氧代123在体外评价4-四氢异喹啉和1-氧代-12-二氢异喹啉支架
6. Nanomolar Inhibitors of CNS Epinephrine Biosynthesis: (R)-(+)-3-Fluoromethyl-7-(N-substituted aminosulfonyl)-1, 2, 3, 4-tetrahydroisoquinolines as Potent and Highly Selective Inhibitors of Phenylethanolamine N-Methyltransferase [O] . -1

机译：CNS肾上腺素生物合成的纳摩尔抑制剂：（R） - （+） - 3-氟甲基-7-（N-取代的氨基磺酰基）-1,2,3,4-四氰基异喹啉，作为苯基乙醇胺N-甲基转移酶的有效和高选择性抑制剂

Inhibitors of Phenylethanolamine N-Methyltransferase That Are Predicted To Penetrate the Blood-Brain Barrier: Design, Synthesis, and Evaluation of 3-Fluoromethyl-7-(N-substituted aminosulfonyl)-1, 2, 3, 4-tetrahydroisoquinolines That Possess Low Affinity toward the a2-Adrenoceptor

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