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Application of PK/PD Modeling and Simulation to Dosing Regimen Optimization of High-Dose Human Regular U-500 Insulin

机译：PK / PD模拟和模拟在高剂量人常规U-500胰岛素中的应用中的应用

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Amparo de la Peña; Xiaosu Ma; Shobha Reddy; Fernando Ovalle; Richard M. Bergenstal; Jeffrey A. Jackson;
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1. Application of PK/PD Modeling and Simulation to Dosing Regimen Optimization of High-Dose Human Regular U-500 Insulin [J] . Amparo de la Pe?a, Xiaosu Ma, Shobha Reddy, Journal of Diabetes Science and Technology . 2014,第4期

机译：PK / PD建模与仿真在大剂量人常规U-500胰岛素剂量方案优化中的应用
2. Pharmacokinetics and pharmacodynamics of high-dose human regular U-500 insulin versus human regular U-100 insulin in healthy obese subjects. [J] . de la Pena A, Riddle M, Morrow LA, Diabetes care . 2011,第12期

机译：高剂量人常规U-500胰岛素与人常规U-100胰岛素在健康肥胖受试者中的药代动力学和药效学。
3. EFFECT OF TOTAL DAILY DOSE ON EFFICACY, DOSING, AND SAFETY OF 2 DOSE TITRATION REGIMENS OF HUMAN REGULAR U-500 INSULIN IN SEVERELY INSULIN-RESISTANT PATIENTS WITH TYPE 2 DIABETES [J] . Wysham Carol, Hood Robert C., Warren Mark L., Endocrine practice: official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists . 2016,第6期

机译：每日总剂量对重度胰岛素抵抗的2型糖尿病患者常规U-500胰岛素2种剂量滴定方案的功效，剂量和安全性的影响
4. A Novel Model for Individual Dosing Regimens Against PK-PD Correlation [C] . Yingzhu Feng, Bochu Wang, Shuangkou Chen, . 2009

机译：针对PK-PD相关性的个体给药方案的新模型
5. The Effect of High-Dose N-Acetylcysteine on Small Airways Function and Exacerbations in COPD Patients [D] . Tse, Hoi Nam. 2019

机译：高剂量N-乙酰半胱氨酸对COPD患者小型气道功能和恶化的影响
6. Application of PK/PD Modeling and Simulation to Dosing Regimen Optimization of High-Dose Human Regular U-500 Insulin [O] . Amparo de la Peña, Xiaosu Ma, Shobha Reddy, 2014

机译：PK / PD建模与仿真在大剂量人常规U-500胰岛素剂量方案优化中的应用
7. Pharmacokinetics and Pharmacodynamics of High-Dose Human Regular U-500 Insulin Versus Human Regular U-100 Insulin in Healthy Obese Subjects. Diabetes Care 2011;34:2496–2501 [O] . Amparo de la Peña, Matthew Riddle, Linda A. Morrow, 2014

机译：高剂量人常规U-500胰岛素对健康肥胖受试者的高剂量人常规U-500胰岛素的药代动力学和药效学。糖尿病护理2011; 34：2496-2501
8. Dose-Rate Dependence of High-Dose Health Effects in Humans from Photon Radiation with Application to Radiological Terrorism [R] . Strom, D. J. 2005

机译：光子辐射对人体大剂量健康影响的剂量率依赖性及其对放射性恐怖主义的应用

Application of PK/PD Modeling and Simulation to Dosing Regimen Optimization of High-Dose Human Regular U-500 Insulin

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