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Heme Modification Contributes to the Mechanism-Based Inactivation of Human Cytochrome P450 2J2 by Two Terminal Acetylenic Compounds

机译：血红素改性有助于通过两个末端乙炔化合物的人细胞色素P450 2J2的基于机制的灭活

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Hsia-lien Lin; Haoming Zhang; Vyvyca J. Walker; Jaime D’Agostino; Paul F. Hollenberg;
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1. Heme Modification Contributes to the Mechanism-Based Inactivation of Human Cytochrome P450 2J2 by Two Terminal Acetylenic Compounds [J] . Lin Hsia-lien, Zhang Haoming, Walker Vyvyca J., Drug Metabolism and Disposition: The Biological Fate of Chemicals . 2017,第9期

机译：血红素改性有助于通过两个末端乙炔化合物对人细胞色素P450 2J2的基于机制的灭活
2. Mechanism-based inactivation of human cytochrome P450 2B6 by clopidogrel: involvement of both covalent modification of cysteinyl residue 475 and loss of heme. [J] . Zhang H, Amunugama H, Ney S, Molecular pharmacology. . 2011,第5期

机译：氯吡格雷对人体细胞色素P450 2B6的基于机制的灭活：半胱氨酸残基475的共价修饰和血红素的损失。
3. Mechanism-based inactivation of cytochromes P450 2E1 and 2E1 T303A by tert-butyl acetylenes: characterization of reactive intermediate adducts to the heme and apoprotein. [J] . Blobaum AL, Kent UM, Alworth WL, Chemical research in toxicology . 2002,第12期

机译：叔丁基乙炔基于机理的细胞色素P450 2E1和2E1 T303A失活：血红素和载脂蛋白反应性中间体加合物的表征。
4. Mutagenesis And Molecular Dynamics Suggest Structural and Functional Roles For of Residues In The N-terminal Portion of The Cytochrome P450 2B1 I Helix [C] . . 2005

机译：诱变和分子动力学表明细胞色素P450 2B1 I螺旋N末端部分中残基的结构和功能作用
5. Part I: Spectroscopic investigations of the heme active site coordination structure of the exogenous ligand-free myoglobin cavity mutant H93G and investigations of H93G-thiolate adducts as structural and mechanistic model systems for cytochrome P450. Part II: Spectroscopic investigations of proximal heme iron ligation in two novel halogenating and dehalogenating peroxidase enzymes isolated from marine sources. [D] . Roach, Mark Patrick. 1997

机译：第一部分：无外源配体的肌红蛋白腔突变体H93G的血红素活性位点配位结构的光谱研究，以及作为细胞色素P450结构和机理模型系统的H93G-硫醇盐加合物的研究。第二部分：从海洋来源分离的两种新型卤化和脱卤过氧化物酶中近端血红素铁连接的光谱研究。
6. Heme Modification Contributes to the Mechanism-Based Inactivation of Human Cytochrome P450 2J2 by Two Terminal Acetylenic Compounds [O] . Hsia-lien Lin, Haoming Zhang, Vyvyca J. Walker, -1

机译：血红素修饰有助于两个末端的乙炔化合物对人体细胞色素P450 2J2的机制失活。
7. Mechanism-Based Inactivation of Human Cytochrome P450 2B6 by Clopidogrel: Involvement of Both Covalent Modification of Cysteinyl Residue 475 and Loss of Heme [O] . Haoming Zhang, Hemali Amunugama, Sarah Ney, 2011

机译：基于机理的人细胞色素P450 2b6通过氯吡格雷灭活：涉及胱抑素475的共价修饰475和血红素损失
8. Relationship of cytochrome caa(sub 3) from Thermus thermophilus to other heme- and copper-containing terminal oxidases. [R] . Mather, M. W., Springer, P., Fee, J. A. 1990

机译：来自嗜热栖热菌的细胞色素caa（sub 3）与其他含血红素和铜的末端氧化酶的关系。

Heme Modification Contributes to the Mechanism-Based Inactivation of Human Cytochrome P450 2J2 by Two Terminal Acetylenic Compounds

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