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Antitumor Activity of a Novel Bispecific Antibody That Targets the ErbB2/ErbB3 Oncogenic Unit and Inhibits Heregulin-Induced Activation of ErbB3

机译：一种新的双特异性抗体的抗肿瘤活性，所述双特异性抗体靶向ERBB2 / ERBB3致癌单元并抑制在这里胰蛋白诱导的ERBB3活化

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Charlotte F. McDonagh; Alexandra Huhalov; Brian D. Harms; Sharlene Adams; Violette Paragas; Shinji Oyama; Bo Zhang; Lia Luus; Ryan Overland; Stephanie Nguyen; Jinming Gu; Neeraj Kohli; Matt Wallace; Michael J. Feldhaus; Arthur J. Kudla; Birgit Schoeberl; Ulrik B. Nielsen;
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1. Antitumor Activity of a Novel Bispecific Antibody That Targets the ErbB2/ErbB3 Oncogenic Unit and Inhibits Heregulin-Induced Activation of ErbB3. [J] . Charlotte F McDonagh, Alexandra Huhalov, Brian D Harms, Molecular cancer therapeutics . 2012,第3期

机译：靶向ErbB2 / ErbB3致癌单元并抑制调蛋白诱导的ErbB3激活的新型双特异性抗体的抗肿瘤活性。
2. Istiratumab (MM-141), A Bispecific Antibody Targeting IGF-1R and ERBB3, Potentiates the Activity of Standard of Care Chemotherapy in In Vivo Models of Ewing Sarcoma [J] . Curley M., Yannatos I., Camblin A., Pediatric blood & cancer . 2016,第Suppla3期

机译：Istiratumab（MM-141），一种靶向IGF-1R和ERBB3的双特异性抗体，可增强尤文氏肉瘤体内模型中护理化学疗法的标准活性。
3. A Novel Bispecific Tetravalent Antibody Fusion Protein to Target Costimulatory Activity for T-cell Activation to Tumor Cells Overexpressing ErbB2/HER2. [J] . Biburger M, Wels WS Journal of Molecular Biology . 2005,第5期

机译：一种新型的双特异性四价抗体融合蛋白，靶向共刺激活性，用于T细胞活化至过度表达ErbB2 / HER2的肿瘤细胞。
4. Bispecific Antibodies Targeting the Ebola Glycoprotein Spike and Its Lysosomal Entry Receptor NPC1 Potently Inhibit Viral Infection [C] . Anna Wec, Elisabeth Nyakatura, Jonathan R. Lai, PEGS . 2015

机译：靶向埃博拉糖蛋白穗及其溶酶体进入受体NPC1的双特异性抗体有效地抑制病毒感染
5. The role ofc-Src in ErbB2/ErbB3 heterocomplex formation and breast cancer. [D] . Ishizawar, Rumey Chang. 2004

机译：c-Src在ErbB2 / ErbB3异源复合物形成和乳腺癌中的作用。
6. Activated T cells from umbilical cord blood armed with anti-CD3 × anti-CD20 bispecific antibody mediate specific cytotoxicity against CD20+ targets with minimal allogeneic reactivity: a strategy for providing antitumor effects after cord blood transplants [O] . Archana Thakur, Carly Sorenson, Oxana Norkina, -1

机译：从脐带血活化的T细胞与抗CD3武装×抗CD20双特异性抗体中介特异性针对以最小的异体反应CD20 +细胞毒性的目标：提供脐带血移植后的抗肿瘤效果的策略
7. FS118, a Bispecific Antibody Targeting LAG-3 and PD-L1, Enhances T-Cell Activation Resulting in Potent Antitumor Activity [O] . Matthew Kraman, Mustapha Faroudi, Natalie L. Allen, 2020

机译：FS118，靶向LAG-3和PD-L1的双特异性抗体增强了T细胞活化，导致有效的抗肿瘤活性
8. Cell Penetrating Bispecific Antibodies for Targeting Oncogenic Transcription Factors in Advanced Prostate Cancer. [R] . Lilly, M., Weisbart, R. 2016

机译：细胞穿透双特异性抗体靶向晚期前列腺癌的致癌转录因子。

Antitumor Activity of a Novel Bispecific Antibody That Targets the ErbB2/ErbB3 Oncogenic Unit and Inhibits Heregulin-Induced Activation of ErbB3

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