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Emerging Substrate Proteins of Kelch-like ECH Associated Protein 1 (Keap1) and Potential Challenges for the Development of Small-Molecule Inhibitors of the Keap1-Nuclear Factor Erythroid 2Related Factor 2 (Nrf2) ProteinProtein Interaction

机译：KELCH样ECH相关蛋白1（KEAP1）的新出现的底物蛋白和用于开发Keap1核因子红外蛋白2重组2（NRF2）蛋白质蛋白相互作用的小分子抑制剂的潜在挑战

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1. Emerging Substrate Proteins of Kelch-like ECH Associated Protein 1 (Keap1) and Potential Challenges for the Development of Small-Molecule Inhibitors of the Keap1-Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Protein-Protein Interaction [J] . Zhang Yong, Shi Zeyu, Zhou Yujun, Journal of Medicinal Chemistry . 2020,第15期

机译：KELCH样ECH相关蛋白1（KEAP1）的新出现的底物蛋白和用于开发Keap1核因子红细胞2相关因子2（NRF2）蛋白质相互作用的小分子抑制剂的潜在挑战
2. Discovery and Development of Kelch-like ECH-Associated Protein 1. Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction Inhibitors: Achievements, Challenges, and Future Directions [J] . Jiang Zheng-Yu, Lu Meng-Chen, You Qi-Dong Journal of Medicinal Chemistry . 2016,第24期

机译：凯尔奇样ECH相关蛋白的发现和发展1.核因子类红细胞2相关因子2（KEAP1：NRF2）蛋白相互作用抑制剂：成就，挑战和未来方向
3. Structure-Activity and Structure-Conformation Relationships of Aryl Propionic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1/Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1/NRF2) Protein-Protein Interaction [J] . Heightman Tom D., Callahan James F., Chiarparin Elisabetta, Journal of Medicinal Chemistry . 2019,第9期

机译：芳基丙酸抑制剂的结构 - 活性和结构构象关系，Kelch样ech相关蛋白1 /核因子红斑2相关因子2（Keap1 / NRF2）蛋白质 - 蛋白质相互作用
4. Prediction of Protein-Peptide Interactions: Application of the XPairIt API to anthrax lethal factor and substrates [C] . Margaret M. Hurley, Michael S. Sellers Smart biomedical and physiological sensor technology X . 2013

机译：蛋白质-肽相互作用的预测：XPairIt API在炭疽致死因子和底物中的应用
5. Toward Better Development of Protein-Protein Interaction Inhibitors: Applications to the beta-Catenin/T-Cell Factor Protein-Protein Interaction [D] . Catrow, Jonathan Leon. 2017

机译：寻求更好的蛋白质-蛋白质相互作用抑制剂的开发：在β-Catenin/ T细胞因子蛋白质-蛋白质相互作用中的应用
6. Replacement of a Naphthalene Scaffold in Kelch-like ECH-Associated Protein 1 (KEAP1)/ Nuclear factor (erythroid-derived 2)-like 2 (NRF2) Inhibitors [O] . Benjamin G. Richardson, Atul D. Jain, Haranatha Potteti, -1

机译：替代Kelch类ECH相关蛋白1（KEAP1）/核因子（类胡萝卜素衍生的2）样2（NRF2）抑制剂中的萘支架。
7. Discovery of a Potent Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1Nrf2) ProteinProtein Interaction Inhibitor with Natural Proline Structure as a Cytoprotective Agent against Acetaminophen-Induced Hepatotoxicity [O] . -1

机译：发现有效的kelch样ech相关蛋白1核因子红细胞2相关因子2（Keap1nRF2）蛋白质蛋白相互作用抑制剂，其具有天然脯氨酸结构，作为抗乙酰氨基酚诱导的肝毒性的细胞保护剂

Emerging Substrate Proteins of Kelch-like ECH Associated Protein 1 (Keap1) and Potential Challenges for the Development of Small-Molecule Inhibitors of the Keap1-Nuclear Factor Erythroid 2Related Factor 2 (Nrf2) ProteinProtein Interaction

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