Jaspamide from the Marine Sponge Jaspis johnstoni

摘要

The toxic deriv. jaspamide, a cyclic depsipeptide, was isolated from the CH2Cl2 ext. of the New Guinean marine sponge J. johnstoni. Its identity was confirmed by high-resoln. fast-atom-bombardment mass, UV, IR, and 1H/1H and 1H/13C correlated 2-dimensional NMR spectroscopy as well as nuclear Overhauser effect expts. and microhydrolysis expts.