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Increased PARP1-DNA binding due to autoPARylation inhibition of PARP1 on DNA rather than PARP1-DNA trapping is correlated with PARP1 inhibitor's cytotoxicity

机译：由于对DNA上的PARP1而不是PARP1-DNA诱捕的PARP1，GARP1-DNA的增加增加与PARP1抑制剂的细胞毒性相关

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Hua-Dong Chen; Chuan-Huizi Chen; Yu-Ting Wang; Ne Guo; Yu-Nan Tian; Xia-Juan Huan; Shan-Shan Song; Jin-Xue He; Ze-Hong Miao;
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1. Increased PARP1-DNA binding due to autoPARylation inhibition of PARP1 on DNA rather than PARP1-DNA trapping is correlated with PARP1 inhibitor's cytotoxicity [J] . Chen Hua-Dong, Chen Chuan-Huizi, Wang Yu-Ting, International Journal of Cancer =: Journal International du Cancer . 2019,第3期

机译：由于对DNA上的PARP1而不是PARP1-DNA诱捕的PARP1引起的PARP1-DNA结合增加与PARP1抑制剂的细胞毒性相关
2. Uncoupling of PARP1 trapping and inhibition using selective PARP1 degradation [J] . Wang Shuai, Han Lei, Han Jungsoo, Nature chemical biology . 2019,第12期

机译：使用选择性PARP1降解的PARP1捕获和抑制的解耦和抑制
3. PARP inhibitors trap PARP1 onto damaged DNA via catalytic inhibition and not by an allosteric mechanism [J] . Hopkins T., Solomon L., Shi Y., European journal of cancer: official journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR) . 2014,第Suppla6期

机译：PARP抑制剂通过催化抑制而不是通过变构机制将PARP1捕获到受损的DNA上
4. DESIGN AND SYNTHESIS OF NOVEL POLY ADP-RIBOSE POLYMERASE 1(PARP1)INHIBITORS FOR THE TREATMENT OF SOLID TUMORS [C] . J.Priyancy, D.P.Bhumika Conference on Drug Design and Discovery Technologies . 2020

机译：用于治疗实体肿瘤的新型聚ADP-核糖聚合酶1（PARP1）抑制剂的设计与合成
5. Poly (ADP-ribose) polymerase 1 (PARP1) and its DNA-binding characteristics. [D] . Kramer, Michael A. 2011

机译：聚（ADP-核糖）聚合酶1（PARP1）及其DNA结合特性。
6. PARP1 inhibitors trigger innate immunity via PARP1 trapping-induced DNA damage response [O] . Chiho Kim, Xu-Dong Wang, Yonghao Yu 2020

机译：PARP1抑制剂通过PARP1捕获诱导的DNA损伤反应引发先天性免疫
7. Histone deacetylase inhibitors decrease NHEJ both by acetylation of repair factors and trapping of PARP1 at DNA double-strand breaks in chromatin [O] . Carine Robert, Pratik K. Nagaria, Nisha Pawar, 2016

机译：组蛋白脱乙酰酶抑制剂通过乙酰化因子乙酰化和染色质DNA双链突破的PARP1捕获而降低NHEJ

Increased PARP1-DNA binding due to autoPARylation inhibition of PARP1 on DNA rather than PARP1-DNA trapping is correlated with PARP1 inhibitor's cytotoxicity

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