This study was conducted to examine the effect of dietary 1.02% sodium phytate on growth, relative weights of tissues, serum cholesterol, liver triglyceride and hepatic aminopyrine N-demethylase activity in rats fed a casein-or amino acid-based diet with or without 0.07% 1,1,1-trichloro-2,2-bis (p-chlorophenyl)ethane(DDT) for 13 days. Dietary DDT and the amino acid-based diet generally suppressed growth rate and food intake. These protein-related effects were significantly alleviated by the administration of dietary phytate. Liver weight, which was generally suppressed by phytate intake, was markedly elevated by DDT intake. In the rats fed diets without DDT, the amino acid-based diet reduced liver weight regardless of dietary phytate intake. Dietary DDT and the amino acid-based diet elevated testis weight and lowered adipose tissue weight. However, the present dietary manipulation had no effect on kidney weight. Dietary DDT significantly elevated serum cholesterol and liver triglyceride levels, as well as the hepatic activity of aminopyrine N-demethylase. This enhancement of serum cholesterol level and hepatic activity of aminopyrine N-demethylase by DDT was especially prominent in rats fed the amino acid-based diet. Dietary DDT enhanced, whereas the amino acid-based diet reduced liver triglyceride levels. Dietary phytate depressed the liver triglyceride levels regardless of DDT intake, but only in rats fed the casein-based diet. This study suggests that some effects of DDT intake might be potentiated by the amino acid-based diet and some effects reliant on protein source might be depressed by phytate intake.
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