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AcrIIA22 is a novel anti-CRISPR that impairs SpyCas9 activity by relieving DNA torsion of target plasmids

机译：Acria22是一种新型的抗CRISPR，通过缓解靶质粒的DNA扭转损害SPYCAS9活性

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Kevin J. Forsberg; Danica T. Schmidtke; Rachel Werther; Deanna Hausman; Barry L. Stoddard; Brett K. Kaiser; Harmit S. Malik;
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1. Inhibition Mechanism of an Anti-CRISPR Suppressor AcrIIA4 Targeting SpyCas9 [J] . Yang Hui, Patel Dinshaw J. Molecular cell . 2017,第1期

机译：抗克切者抑制剂Acriia4靶向SPYCAS9的抑制机制
2. Targeted delivery of plasmid DNA to hepatocytes in vivo: optimization of the pharmacokinetics of plasmid DNA/galactosylated poly(L-lysine) complexes by controlling their physicochemical properties. [J] . Nishikawa M, Takemura S, Takakura Y, The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics . 1998,第1期

机译：体内将质粒DNA靶向递送到肝细胞：通过控制质粒DNA /半乳糖基化聚（L-赖氨酸）复合物的理化特性，优化其药代动力学。
3. Facilitation of DNA self-assembly by relieving the torsional strains between building blocks [J] . Weili Shen, Qing Liu, Baoquan Ding, Organic & biomolecular chemistry . 2017,第2期

机译：通过减轻构件之间的扭转应力来促进DNA自组装
4. Preparation and Characterisation of Targeted Chitosan-Plasmid DNA Nanoparticles [C] . E. Talvitie, K. Paavilainen, J. Leppiniemi, European conference on biomaterials;ESB 2010 . 2010

机译：靶向壳聚糖-质粒DNA纳米粒子的制备与表征
5. Targeting DNA expression and hybridization with light: Application to plasmid transfections and antisense oligodeoxynucleotides. [D] . Monroe, William Todd. 2001

机译：靶向DNA表达和光杂交：应用于质粒转染和反义寡脱氧核苷酸。
6. Inhibition Mechanism of an Anti-CRISPR Suppressor AcrIIA4 Targeting SpyCas9 [O] . Hui Yang, Dinshaw J. Patel -1

机译：靶向SpyCas9的抗CRISPR抑制剂AcrIIA4的抑制机制
7. In the absence of writhe, DNA relieves torsional stress with localized, sequence-dependent structural failure to preserve B-form [O] . Randall, Graham L., Zechiedrich, Lynn, Pettitt, B. Montgomery 2009

机译：在没有扭曲的情况下，DNA通过局部，依赖序列的结构破坏来减轻扭转应力，从而保持B型

AcrIIA22 is a novel anti-CRISPR that impairs SpyCas9 activity by relieving DNA torsion of target plasmids

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