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The Novel ATP-Competitive MEK/Aurora Kinase Inhibitor BI-847325 Overcomes Acquired BRAF Inhibitor Resistance through Suppression of Mcl-1 and MEK Expression

机译：新型ATP竞争性MEK / Aurora激酶抑制剂BI-847325通过抑制MCL-1和MEK表达来克服获得的BRAF抑制剂抗性

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Manali S. Phadke; Patrizia Sini; Keiran S.M. Smalley;
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1. The Novel ATP-Competitive MEK/Aurora Kinase Inhibitor BI-847325 Overcomes Acquired BRAF Inhibitor Resistance through Suppression of Mcl-1 and MEK Expression [J] . Phadke Manali S., Sini Patrizia, Smalley Keiran S. M. Molecular cancer therapeutics . 2015,第6期

机译：新型ATP竞争性MEK / Aurora激酶抑制剂BI-847325通过抑制MCL-1和MEK表达来克服获得的BRAF抑制剂抗性
2. Combinations of BRAF, MEK, and PI3K/mTOR Inhibitors Overcome Acquired Resistance to the BRAF Inhibitor GSK2118436 Dabrafenib, Mediated by NRAS or MEK Mutations. [J] . James G Greger, Stephen D Eastman, Vivian Zhang, Molecular cancer therapeutics . 2012,第4期

机译：由NRAS或MEK突变介导的BRAF，MEK和PI3K / mTOR抑制剂的组合克服了对BRAF抑制剂GSK2118436 Dabrafenib的获得性耐药。
3. Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K. [J] . Villanueva J, Vultur A, Lee JT, Cancer Cell . 2010,第6期

机译：通过将MEK和IGF-1R / PI3K共同靶向可以克服黑色素瘤中由RAF激酶开关介导的对BRAF抑制剂的耐药性。
4. Network Entropy Reveals that Cancer Resistance to MEK Inhibitors Is Driven by the Resilience of Proliferative Signaling [C] . Joel Maust, Judith Leopold, Andrej Bugrim International Conference on Complex Networks and Their Applications . 2020

机译：网络熵揭示了对MEK抑制剂的抗性抗性由增殖信号传导的抗性驱动
5. Optimizing MEK Inhibitors in NRAS Mutant Melanoma - Overcoming Resistance and Combination Strategies [D] . Nguyen, Mai. 2021

机译：优化NRAS突变体黑素瘤耐久性和组合策略中的MEK抑制剂
6. The novel ATP-competitive MEK/Aurora kinase inhibitor BI-847325 overcomes acquired BRAF inhibitor resistance through suppression of Mcl-1 and MEK expression [O] . Manali S. Phadke, Patrizia Sini, Keiran S. M. Smalley -1

机译：新型具有ATP竞争能力的MEK / Aurora激酶抑制剂BI-847325通过抑制Mcl-1和MEK表达克服了获得性BRAF抑制剂耐药性
7. Combinations of BRAF, MEK, and PI3K/mTOR Inhibitors Overcome Acquired Resistance to the BRAF Inhibitor GSK2118436 Dabrafenib, Mediated by NRAS or MEK Mutations [O] . James G. Greger, Stephen D. Eastman, Vivian Zhang, 2012

机译：BRAF，MEK和PI3K / MTOR抑制剂的组合克服了由NRAS或MEK突变介导的BRAF抑制剂GSK2118436 Dabrafenib的获得性抗性

The Novel ATP-Competitive MEK/Aurora Kinase Inhibitor BI-847325 Overcomes Acquired BRAF Inhibitor Resistance through Suppression of Mcl-1 and MEK Expression

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