首页> 外文OA文献 >Discovery of N-(3-Carbamoyl-5,5,7,7-tetramethyl-5,7-dihydro-4H-thieno2,3-cpyran-2-yl)-lH-pyrazole-5-carboxamide (GLPG1837), a Novel Potentiator Which Can Open Class III Mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Channels to a High Extent

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Discovery of N-(3-Carbamoyl-5,5,7,7-tetramethyl-5,7-dihydro-4H-thieno2,3-cpyran-2-yl)-lH-pyrazole-5-carboxamide (GLPG1837), a Novel Potentiator Which Can Open Class III Mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Channels to a High Extent

机译：发现N-（3-氨基甲酰基-5,5,7,7-四甲基-5,7-二氢-4H-Thieno 2,3-C Pyran-2-Y1）-LH-吡唑-5-甲酰胺（ GLPG1837），一种新型强剂，可在高度上开放III类突变体囊性纤维化跨膜电导调节器（CFTR）通道

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Steven E. Van der Plas; Hans Kelgtermans; Tom De Munck; Sébastien L. X. Martina; Sébastien Dropsit; Evelyne Quinton; Ann De Blieck; Caroline Joannesse; Linda Tomaskovic; Mia Jans; Thierry Christophe; Ellen van der Aar; Monica Borgonovi; Luc Nelles; Maarten Gees; Pieter Stouten; Jan Van Der Schueren; Oscar Mammoliti; Katja Conrath; Martin Andrews;
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1. Discovery of N-(3-Carbamoyl-5,5,7,7-tetramethyl-5,7-dihydro-4H-thieno[2,3-c]pyran-2-yl)-lH-pyrazole-5-carboxamide (GLPG1837), a Novel Potentiator Which Can Open Class III Mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Channels to a High Extent [J] . Van der Plas Steven E., Kelgtermans Hans, De Munck Tom, Journal of Medicinal Chemistry . 2018,第4期

机译：发现N-（3-氨基甲酰基-5,5,7,7-四甲基-5,7-二氢-4H-Thieno [2,3-C] Pyran-2-Y1）-LH-吡唑-5-甲酰胺（ GLPG1837），一种新型强剂，可在高度上开放III类突变体囊性纤维化跨膜电导调节器（CFTR）通道
2. Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Potentiator VX-770 (Ivacaftor) Opens the Defective Channel Gate of Mutant CFTR in a Phosphorylation-dependent but ATP-independent Manner [J] . Paul W. Eckford, Canhui Li, Mohabir Ramjeesingh, The Journal of biological chemistry . 2012,第44期

机译：囊性纤维化跨膜电导调节器（CFTR）电位器VX-770（IVACAFTOR）在依赖于磷酸化但ATP独立的方式中打开突变体CFTR的缺陷通道栅极
3. Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Potentiators Protect G551D but Not ΔF508 CFTR from Thermal Instability [J] . Xuehong Liu, David C. Dawson Biochemistry . 2014,第35期

机译：囊性纤维化跨膜电导调节器（CFTR）增强剂保护G551D但不是ΔF508CFTR从热不稳定性
4. Quantitative mass spectrometry for analysis of membrane expression of cystic fibrosis transmembrane conductance regulator (CFTR) [C] . Alexis A. Ramos, Bonita A. Coutermarsh, Pamela C. Diego, ASMS Conference on Mass Spectrometry and Allied Topics . 2008

机译：囊性纤维化跨膜电导调节器（CFTR）膜表达分析的定量质谱
5. The cystic fibrosis transmembrane conductance regulator (CFTR) channel as a host determinant of influenza severity. [D] . Woods, Parker. 2016

机译：囊性纤维化跨膜电导调节器（CFTR）通道是流感严重程度的宿主决定因素。
6. Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Potentiator VX-770 (Ivacaftor) Opens the Defective Channel Gate of Mutant CFTR in a Phosphorylation-dependent but ATP-independent Manner [O] . Paul D. W. Eckford, Canhui Li, Mohabir Ramjeesingh, 2012

机译：囊性纤维化跨膜电导调节剂（CFTR）增效剂VX-770（Ivacaftor）以依赖磷酸化但不依赖ATP的方式打开突变CFTR的缺陷通道门
7. Differential Sensitivity of the Cystic Fibrosis (CF)-associated Mutants G551D and G1349D to Potentiators of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Cl– Channel [O] . Zhiwei Cai, Alessandro Taddei, David N. Sheppard 2006

机译：囊性纤维化（CF） - 分配突变体G551D和G1349D对囊性纤维化跨膜电导调节器（CFTR）的增强剂的差异敏感性

Discovery of N-(3-Carbamoyl-5,5,7,7-tetramethyl-5,7-dihydro-4H-thieno2,3-cpyran-2-yl)-lH-pyrazole-5-carboxamide (GLPG1837), a Novel Potentiator Which Can Open Class III Mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Channels to a High Extent

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