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Affinity Maturation to Improve Human Monoclonal Antibody Neutralization Potency and Breadth against Hepatitis C Virus

机译：亲和力成熟，以改善人单克隆抗体中和效力和丙型肝炎病毒的广度

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Yong Wang; Zhen-yong Keck; Anasuya Saha; Jinming Xia; Fraser Conrad; Jianlong Lou; Michael Eckart; James D. Marks; Steven K.H. Foung;
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年度 2011
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1. Affinity Maturation to Improve Human Monoclonal Antibody Neutralization Potency and Breadth against Hepatitis C Virus [J] . Yong Wang, Zhen-yong Keck, Anasuya Saha, The Journal of biological chemistry . 2011,第51期

机译：亲和力成熟，以改善人单克隆抗体中和效力和丙型肝炎病毒的广度
2. Affinity maturation by targeted diversification of the CDR-H2 loop of a monoclonal Fab derived from a synthetic naive human antibody library and directed against the internal trimeric coiled-coil of gp41 yields a set of Fabs with improved HIV-1 neutralization potency and breadth. [J] . Gustchina E, Louis JM, Frisch C Virology . 2009,第1期

机译：通过衍生自合成的天然人抗体文库并针对gp41的内部三聚体卷曲螺旋的单克隆Fab的CDR-H2环的靶向多样化，进行亲和力成熟，可以生产出具有改善的HIV-1中和力和广度的Fab。
3. Affinity Maturation of a Broadly Neutralizing Human Monoclonal Antibody That Prevents Acute Hepatitis C Virus Infection in Mice [J] . Keck Zhen-Yong, Wang Yong, Lau Patrick, Hepatology: Official Journal of the American Association for the Study of Liver Diseases . 2016,第6期

机译：广泛中和的人类单克隆抗体，可防止小鼠急性丙型肝炎病毒感染的亲和力成熟。
4. Identification of Type-Common and Neutralization Epitopes on Hepatitis E Virus Genotype 4 by Using Monoclonal Antibodies [C] . Hongmei Zhang, Xing Dai, Xiangnian Shan, International Forum on Progress on Post-Genome Technologies(5'IFPT); 20070910-11; Suzhou(CN) . 2007

机译：使用单克隆抗体鉴定戊型肝炎病毒基因型4的常见类型和中和表位
5. Measuring hepatitis C virus specific neutralizing antibodies in humans [D] . Dowd, Kimberly A. 2008

机译：测量人类中的丙型肝炎病毒特异性中和抗体
6. Affinity Maturation to Improve Human Monoclonal Antibody Neutralization Potency and Breadth against Hepatitis C Virus [O] . Yong Wang, Zhen-yong Keck, Anasuya Saha, 2011

机译：亲和力成熟以提高人类单克隆抗体中和能力和广度抗丙型肝炎病毒
7. Affinity maturation by targeted diversification of the CDR-H2 loop of a monoclonal Fab derived from a synthetic naïve human antibody library and directed against the internal trimeric coiled-coil of gp41 yields a set of Fabs with improved HIV-1 neutralization potency and breadth [O] . Gustchina Elena, Louis John M., Frisch Christian, 2009

机译：通过定向衍生自原始人工人类抗体文库并针对gp41内部三聚体卷曲螺旋的单克隆Fab的CDR-H2环进行靶向多样化的亲和力成熟，可产生具有改善的HIV-1中和力和广度的Fab集合

Affinity Maturation to Improve Human Monoclonal Antibody Neutralization Potency and Breadth against Hepatitis C Virus

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