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Glancing-Angle Deposition of Nanostructures on an Implant Material Surface

机译:纳米结构对植入物材料表面的渗透角沉积

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摘要

Cell-compatible and antibacterial surfaces are needed for implants, which frequently have complex and rough surfaces. Bio-inspired columnar nanostructures can be grown on flat substrates; however, the application of these nanostructures on clinically relevant, complex, and rough surfaces was pending. Therefore, a titanium plasma spray (TPS) implant surface was coated with titanium nano-spikes via glancing angle magnetron sputter deposition (GLAD) at room temperature. Using GLAD, it was possible to cover the three-dimensional, highly structured macroscopic surface (including cavities, niches, clefts, and curved areas) of the TPS homogeneously with nano-spikes (TPS+), creating a cell-compatible and antibacterial surface. The adherence and spreading of mesenchymal stem cells (MSC) were similar for TPS and TPS+ surfaces. However, MSC adherent to TPS+ expressed less and shorter pseudopodia. The induced osteogenic response of MSC was significantly increased in cells cultivated on TPS+ compared with TPS. In addition, Gram-negative bacteria (E. coli) adherent to the nano-spikes were partly destructed by a physico-mechanical mechanism; however, Gram-positive bacteria (S. aureus) were not significantly damaged.
机译:植入物需要细胞相容性和抗菌表面,其经常具有复杂和粗糙的表面。生物启发的柱状纳米结构可以在扁平基材上生长;然而,这些纳米结构在临床相关,复杂和粗糙表面上施用待定。因此,通过在室温下通过瞥见角度磁控溅射沉积(高兴)涂覆钛等离子体喷雾(TPS)植入物表面涂覆钛纳米峰值。使用GRAND,可以覆盖与纳米穗(TPS +)均匀地覆盖TP的三维高度结构的宏观表面(包括TPS的腔,效力,裂缝和弯曲区域,产生细胞相容性和抗菌表面。间充质干细胞(MSC)的粘附和扩散对于TPS和TPS +表面类似。然而,MSC粘附到TPS +表达较短的假透视性。与TPS相比,在TPS +上培养的细胞中,MSC的诱导的成骨响应显着增加。此外,通过物理机械机制部分地破坏了纳米钉粘附的革兰氏阴性细菌(大肠杆菌);然而,革兰氏阳性细菌(金黄色葡萄球菌)没有显着损害。

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