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Population Pharmacokinetic Analysis of BMS‐986166, a Novel Selective Sphingosine‐1‐Phosphate‐1 Receptor Modulator, and Exposure‐Response Assessment of Lymphocyte Counts and Heart Rate in Healthy Participants

机译：BMS-986166的人口药代动力学分析，一种新颖的选择性鞘氨酸-1-磷酸-1受体调节剂，以及淋巴细胞计数和健康参与者心率的暴露 - 反应评估

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Sébastien Bihorel; Shalabh Singhal; Diane Shevell; Huadong Sun; Jenny Xie; Shenita Basdeo; Ang Liu; Santanu Dutta; Elizabeth Ludwig; Hannah Huang; Kuan‐ju Lin; Aberra Fura; John Throup; Ihab G. Girgis;
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1. Identification and Preclinical Pharmacology of ((1R,3S)-1-Amino-3-((S)-6-(2-methoxyphenethyl)-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentyl)methanol (BMS-986166): A Differentiated Sphingosine-1-phosphate Receptor 1 (S1P(1)) Modulator Advanced into Clinical Trials [J] . Gilmore John L., Xiao Hai-Yun, Dhar T. G. Murali, Journal of Medicinal Chemistry . 2019,第5期

机译：（（（1R，3S）-1-氨基-3 - （（S）-6-（2-甲氧基乙基）-5,6,7,8-四氢萘-2-基）环戊基）甲醇（BMS的鉴定和临床前药理）（BMS -986166）：分化的鞘氨氨酸-1-磷酸酯受体1（S1P（1））调节剂进入临床试验
2. Evaluation of species difference in peripheral lymphocyte reduction effect of CS-0777, a sphingosine 1-phosphate receptor modulator, based on a pharmacokinetic/pharmacodynamic model analysis [J] . Inaba Shin-ichi, Goto Maki, Tanaka-takanaka Kaoru, Biopharmaceutics and Drug Disposition . 2016,第9期

机译：基于药代动力学/药效学模型分析，评估鞘氨醇1-磷酸受体调节剂CS-0777的外周血淋巴细胞减少作用的物种差异
3. Pharmacological modulation of peripheral T and B lymphocytes by a selective sphingosine 1-phosphate receptor-1 modulator [J] . MoberlyJ.B., RohatagiS., ZahirH., The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology . 2012,第7期

机译：选择性鞘氨醇1-磷酸受体1调节剂对外周T和B淋巴细胞的药理调节
4. Heart Rate Variability and Multi-Site Pulse Rate Variability for the Assessment of Autonomic Responses to Whole-Body Cold Exposure [C] . Elisa Mejía-Mejía, Karthik Budidha, Tomas Ysehak Abay, Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2020

机译：心率变异性和多站点脉搏率变异性用于评估对全身冷暴露的自主反应
5. The selective sphingosine 1-phosphate receptor modulator BAF312 redirects lymphocyte distribution and has species-specific effects on heart rate [O] . P Gergely, B Nuesslein-Hildesheim, D Guerini, 2012

机译：选择性鞘氨醇1-磷酸受体调节剂BAF312重定向淋巴细胞分布并对心率具有种特异性影响
6. THU0190 THE SAFETY, PHARMACOKINETICS, AND PHARMACODYNAMICS OF BMS-986166, A NOVEL, SELECTIVE, PARTIAL AGONIST OF THE SPHINGOSINE-1-PHOSPHATE (S1P) SUBTYPE 1 RECEPTOR IN HEALTHY PARTICIPANTS [O] . Shalabh Singhal, Ihab Girgis, Jenny Xie, 2019

机译：THU0190 BMS-986166的安全性，药代动力学和药效学，一种新的，一种选择性，部分激动剂在健康参与者中的鞘氨氨酸-1-磷酸盐（S1P）亚型1受体中的一种新颖，选择性的部分激动剂

Population Pharmacokinetic Analysis of BMS‐986166, a Novel Selective Sphingosine‐1‐Phosphate‐1 Receptor Modulator, and Exposure‐Response Assessment of Lymphocyte Counts and Heart Rate in Healthy Participants

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