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Discovery of piperidine-substituted thiazolo5,4-dpyrimidine derivatives as potent and orally bioavailable HIV-1 non-nucleoside reverse transcriptase inhibitors

机译：发现哌啶 - 取代的噻唑啉5,4-D嘧啶衍生物作为有效和口服生物可利用的HIV-1非核苷逆转录酶抑制剂

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Dongwei Kang; Tong Zhao; Zhao Wang; Da Feng; Heng Zhang; Boshi Huang; Gaochan Wu; Fenju Wei; Zhongxia Zhou; Lanlan Jing; Xiaofang Zuo; Ye Tian; Vasanthanathan Poongavanam; Jacob Kongsted; Erik De Clercq; Christophe Pannecouque; Peng Zhan; Xinyong Liu;
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1. Discovery of piperidine-substituted thiazolo[5,4- d ]pyrimidine derivatives as potent and orally bioavailable HIV-1 non-nucleoside reverse transcriptase inhibitors [J] . Dongwei Kang, Tong Zhao, Zhao Wang, Communications Chemistry . 2019,第1期

机译：发现哌啶 - 取代的噻唑啉[5,4- D]嘧啶衍生物作为有效和口服生物可利用的HIV-1非核苷逆转录酶抑制剂
2. Discovery of 3-{5-[(6-Amino-1H-pyrazolo[3,4-b]pyridine-3-yl)methoxy]-2-chlorophenoxy}-5-chlorobenzonitrile (MK-4965): A Potent, Orally Bioavailable HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitor with Improved Potency against Key Mutant Viruses [J] . Tucker TJ, Sisko JT, Tynebor RM, Journal of Medicinal Chemistry . 2008,第20期

机译：3- {5-[（6-氨基-1H-吡唑并[3,4-b]吡啶-3-基）甲氧基] -2-氯苯氧基} -5-氯苄腈（MK-4965）的发现：口服有效具有生物利用度的HIV-1非核苷逆转录酶抑制剂对关键突变病毒具有增强的效力
3. Quinoxalinylethylpyridylthioureas (QXPTs) as potent non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors. Further SAR studies and identification of a novel orally bioavailable hydrazine-based antiviral agent. [J] . Campiani G, Aiello F, Fabbrini M, Journal of Medicinal Chemistry . 2001,第3期

机译：喹喔啉基乙基吡啶基硫脲（QXPTs）作为有效的非核苷HIV-1逆转录酶（RT）抑制剂。 SAR的进一步研究和新型口服生物利用肼基抗病毒剂的鉴定。
4. Design and Discovery of Diarylpyridines and Diarylanilines as Novel Potent Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors [C] . Bingjie Qin, Xingtao Tian, Xingkai Jiang, ICMSI;International conference of molecular simulations and applied informatics technologies . 2010

机译：二芳基吡啶和二芳基苯胺作为新型有效的非核苷HIV-1逆转录酶抑制剂的设计和发现
5. Biochemical characterization of human immunodeficiency virus type 1 reverse transcriptase mutants to non-nucleoside reverse transcriptase inhibitors [D] . Domaoal, Robert A. 2005

机译：人类免疫缺陷病毒1型逆转录酶突变体对非核苷类逆转录酶抑制剂的生化特性
6. Discovery of diarylpyridine derivatives as novel non-nucleoside HIV-1 reverse transcriptase inhibitors [O] . Xingtao Tian, Bingjie Qin, Hong Lu, -1

机译：作为新型非核苷HIV-1逆转录酶抑制剂的衍生物发现二芳基吡啶衍生物
7. Quinoxalinylethylpyridylthioureas (QXPTs) as potent non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors. Further SAR studies and identification of a novel orally bioavailable hydrazine-based antiviral agent [O] . Campiani, G., Aiello, F., Fabbrini, M., 2001

机译：喹喔啉乙基吡啶硫脲（QXpTs）作为有效的非核苷HIV-1逆转录酶（RT）抑制剂。进一步的saR研究和鉴定一种新的口服生物可利用的肼基抗病毒剂

Discovery of piperidine-substituted thiazolo5,4-dpyrimidine derivatives as potent and orally bioavailable HIV-1 non-nucleoside reverse transcriptase inhibitors

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