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A Novel Point Mutation in the Ligand-Binding Domain (LBD) of the Human Glucocorticoid Receptor (hGR) Causing Generalized Glucocorticoid Resistance: The Importance of the C Terminus of hGR LBD in Conferring Transactivational Activity

机译：人糖皮质激素受体（HGR）的配体结合结构域（LBD）中的一种新型点突变，引起广泛的糖皮质激素抗性：HGR LBD中C末端在赋予反式激活活性的重要性

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Evangelia Charmandari; Annaswamy Raji; Tomoshige Kino; Takamasa Ichijo; Anatoly Tiulpakov; Keith Zachman; George P. Chrousos;
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1. Molecular modelling of the human glucocorticoid receptor (hGR) ligand-binding domain (LBD) by homology with the human estrogen receptor alpha (hERalpha) LBD: quantitative structure-activity relationships within a series of CYP3A4 inducers where induc [J] . Lewis DF, Ogg MS, Goldfarb PS, The Journal of Steroid Biochemistry and Molecular Biology . 2002,第2a3期

机译：通过与人雌激素受体α（hERalpha）LBD的同源性对人糖皮质激素受体（hGR）配体结合域（LBD）进行分子建模：一系列CYP3A4诱导剂中的定量结构-活性关系
2. A Novel Point Mutation in Helix 10 of the Human Glucocorticoid Receptor Causes Generalized Glucocorticoid Resistance by Disrupting the Structure of the Ligand-Binding Domain [J] . Nancy Nader, Bert E. Bachrach, Darrell E. Hurt, The journal of clinical endocrinology and metabolism . 2010,第5期

机译：人糖皮质激素受体的螺旋10中的一种新型点突变通过破坏配体结合结构域的结构而引起广泛的糖皮质激素抗性
3. The Physiology of Human Glucocorticoid Receptor β (hGRβ) and Glucocorticoid Resistance [J] . LAURA J. LEWIS-TUFFIN, JOHN A. CIDLOWSKI Annals of the New York Academy of Sciences . 2006,第Jun期

机译：人糖皮质激素受体β（hGRβ）的生理和糖皮质激素抵抗
4. A New Transcript Splice Variant of the Human Glucocorticoid Receptor: Identification and Tissue Distribution of hGR△313-338, an Alternative Exon 2 Transactivation Domain Isoform [C] . JONATHAN D. TURNER, ANDREA B. SCHOTE, MARC KEIPES, Meeting on Cell Signaling World: Signal Transduction Pathways as Therapeutic Targets . 2007

机译：人糖皮质激素受体的一个新的转录剪接变体：hGR△313-338，另一外显子2反式激活域同工型的鉴定和组织分布。
5. The cloning and expression of the ligand-binding domains of glucocorticoid and estrogen receptors. [D] . Xu, Yan. 2009

机译：糖皮质激素和雌激素受体的配体结合域的克隆和表达。
6. A Novel Point Mutation in Helix 10 of the Human Glucocorticoid Receptor Causes Generalized Glucocorticoid Resistance by Disrupting the Structure of the Ligand-Binding Domain [O] . Nancy Nader, Bert E. Bachrach, Darrell E. Hurt, -1

机译：人糖皮质激素受体的螺旋10中的新型点突变通过破坏配体结合域的结构导致广义糖皮质激素抵抗。
7. A Novel Point Mutation in Helix 10 of the Human Glucocorticoid Receptor Causes Generalized Glucocorticoid Resistance by Disrupting the Structure of the Ligand-Binding Domain [O] . Nader, Nancy, Bachrach, Bert E., Hurt, Darrell E., 2010

机译：人糖皮质激素受体螺旋10中的新型点突变通过破坏配体结合域的结构导致广义糖皮质激素抵抗。

A Novel Point Mutation in the Ligand-Binding Domain (LBD) of the Human Glucocorticoid Receptor (hGR) Causing Generalized Glucocorticoid Resistance: The Importance of the C Terminus of hGR LBD in Conferring Transactivational Activity

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