Bullous systemic lupus erythematosus associated with lupus nephritis: report of two cases

摘要

Bullous systemic lupus erythematosus is recognized as a distinct entity related to autoimmunity to type VII collagen. In some cases, the flare of bullous disease coincides with the exacerbation of systemic lupus erythematosus, and especially lupus nephritis. Two cases of young female patients with vesiculobullous eruption on sun-exposed and non-exposed areas associated to lupus nephritis are described. Diagnosis was proved by characteristic histopathology and direct immunofluorescence. Corticosteroids and dapsone therapy may be effective.