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Blockade of EGFR and ErbB2 by the Novel Dual EGFR and ErbB2 Tyrosine Kinase Inhibitor GW572016 Sensitizes Human Colon Carcinoma GEO Cells to Apoptosis

机译：通过新型双EGFR和ERBB2酪氨酸激酶抑制剂GW572016阻断EGFR和ERBB2敏感人结肠癌地理细胞对细胞凋亡

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Yunfei Zhou; Song Li; Yi P. Hu; Jing Wang; Jennie Hauser; Alexis N. Conway; Michelle A. Vinci; Lisa Humphrey; Elizabeth Zborowska; James K.V. Willson; Michael G. Brattain;
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1. Truncated ErbB2 receptor (p95ErbB2) is regulated by heregulin through heterodimer formation with ErbB3 yet remains sensitive to the dual EGFR|[sol]|ErbB2 kinase inhibitor GW572016 [J] . Wenle Xia, Lei-Hua Liu, Peter Ho, Oncogene . 2004,第3期

机译：截短的ErbB2受体（p95ErbB2）受调蛋白通过与ErbB3异源二聚体形成的调控，但仍对双重EGFR | [sol] | ErbB2激酶抑制剂GW572016敏感
2. Novel irreversible EGFR tyrosine kinase inhibitor 324674 sensitizes human colon carcinoma HT29 and SW480 cells to apoptosis by blocking the EGFR pathway. [J] . Yu Z, Cui B, Jin Y, Biochemical and Biophysical Research Communications . 2011,第4期

机译：新型不可逆的EGFR酪氨酸激酶抑制剂324674通过阻断EGFR途径使人结肠癌HT29和SW480细胞对细胞凋亡敏感。
3. Novel pyrazolo[3,4- d ]pyrimidines: design, synthesis, anticancer activity, dual EGFR/ErbB2 receptor tyrosine kinases inhibitory activity, effects on cell cycle profile and caspase-3-mediated apoptosis [J] . Mai Maher, Asmaa E. Kassab, Ashraf F. Zaher, Journal of enzyme inhibition and medicinal chemistry. . 2019,第1期

机译：新型吡唑并[3,4-d]嘧啶：设计，合成，抗癌活性，EGFR / ErbB2受体酪氨酸激酶双重抑制活性，对细胞周期和caspase-3介导的细胞凋亡的影响
4. Predictive Efficacy of Low Burden EGFR Mutation Detected by Next-Generation Sequencing on Response to EGFR Tyrosine Kinase Inhibitors in Non-Small-Cell Lung Carcinoma [C] . Yeul Hong Kim, Hye Sook Kim, Jae Sook Sung, Molecular Medicine TRI-CON. . 2014

机译：下一代测序对非小细胞肺癌抗蛋白酶激酶抑制剂进行下一代测序检测的低负荷EGFR突变的预测疗效
5. Targeting EGFR and ErbB2 by small molecule tyrosine kinase inhibitors in human colon cancer. [D] . Zhou, Yunfei. 2005

机译：小分子酪氨酸激酶抑制剂在人结肠癌中靶向EGFR和ErbB2。
6. Novel pyrazolo34-dpyrimidines: design synthesis anticancer activity dual EGFR/ErbB2 receptor tyrosine kinases inhibitory activity effects on cell cycle profile and caspase-3-mediated apoptosis [O] . Mai Maher, Asmaa E. Kassab, Ashraf F. Zaher, 2019

机译：新型吡唑并34-d嘧啶：设计合成抗癌活性EGFR / ErbB2受体酪氨酸激酶双重抑制活性对细胞周期和caspase-3介导的细胞凋亡的影响
7. Truncated ErbB2 receptor (p95ErbB2) is regulated by heregulin through heterodimer formation with ErbB3 yet remains sensitive to the dual EGFR/ErbB2 kinase inhibitor GW572016 [O] . Wenle Xia, Lei-Hua Liu, Peter Ho, 2004

机译：截短的ErbB2受体（的p95ErbB2）由调蛋白通过异二聚体的形成与ErbB3的调节但仍然到双EGFR敏感/ ErbB2的激酶抑制剂GW572016

Blockade of EGFR and ErbB2 by the Novel Dual EGFR and ErbB2 Tyrosine Kinase Inhibitor GW572016 Sensitizes Human Colon Carcinoma GEO Cells to Apoptosis

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