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Bringing the Heavy Chain to Light: Creating a Symmetric, Bivalent IgG-Like Bispecific

机译：将沉重的链带来光线：创造一个对称的，二价IgG样的双特异性

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Anusuya Ramasubramanian; Rachel Tennyson; Maureen Magnay; Sagar Kathuria; Tara Travaline; Annu Jain; Dana M. Lord; Megan Salemi; Caitlin Sullivan; Tristan Magnay; Jiali Hu; Eva Bric-Furlong; Pierrick Rival; Yanfeng Zhou; Dietmar Hoffmann; William Brondyk; Katarina Radošević; Partha S. Chowdhury;
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1. Cysteine-SILAC Mass Spectrometry Enabling the Identification and Quantitation of Scrambled Interchain Disulfide Bonds: Preservation of Native Heavy-Light Chain Pairing in Bispecific IgGs Generated by Controlled Fab-arm Exchange [J] . van den Bremer Ewald T. J., Labrijn Aran F., van den Boogaard Ramon, Analytical chemistry . 2017,第20期

机译：半胱氨酸 - 硅胶质谱，从而能够鉴定和定量加扰的连续三硫化键：受控Fab-臂交换产生的双特异性IgG中的天然重链配对
2. Computational design of a specific heavy chain/κ light chain interface for expressing fully IgG bispecific antibodies [J] . Froning K. J., Leaver‐Fay A., Wu X., Protein Science: A Publication of the Protein Society . 2017,第10期

机译：特定重链/κ轻链界面的计算设计表达完全IgG双特异性抗体
3. Preferential species-restricted heavy/light chain pairing in rat/mouse quadromas. Implications for a single-step purification of bispecific antibodies. [J] . Lindhofer H, Mocikat R, Steipe B, The Journal of Immunology: Official Journal of the American Association of Immunologists . 1995,第1期

机译：大鼠/小鼠四倍体瘤中受种限制的重/轻链配对优先。单步纯化双特异性抗体的意义。
4. A Platform Purification Process for Kλ-Bodies, the Novel Bispecific Format Based on Light Chain Diversity [C] . Nicolas Fouque, PA. Cayatte, AJ. Jordana, PEGS . 2015

机译：基于轻链分集的新型双特异性格式的平台净化过程
5. Studies on the Construction of Artificial Antibody Light Chain, Light and Heavy Chain Fittings and Antigen-Antibody Interactions [D] . 薛漢兵, /セツカンヘイ 2019

机译：人工抗体轻链，轻链和重链配件的构建及抗原-抗体相互作用的研究
6. Bringing the Heavy Chain to Light: Creating a Symmetric Bivalent IgG-Like Bispecific [O] . Anusuya Ramasubramanian, Rachel Tennyson, Maureen Magnay, 2020

机译：将沉重的链带来光线：创造一个对称的二价IgG样的双特异性
7. Heavy and light chain pairing of bivalent quadroma and knobs-into-holes antibodies analyzed by UHR-ESI-QTOF mass spectrometry [O] . Wolfgang Schaefer, Hans R Völger, Stefan Lorenz, 2015

机译：通过UHR-ESI-QTOF质谱法分析的厚度和轻链配对二价四瘤和旋钮入孔抗体
8. Use of Combinatorial Heavy and Light Chain Libraries and Site SpecificMutagenesis to Create Antibody Biosensors for Metal Ions [R] . Benkovic, S. J. 1997

机译：使用组合重链和轻链文库和位点特异性突变为金属离子创建抗体生物传感器

Bringing the Heavy Chain to Light: Creating a Symmetric, Bivalent IgG-Like Bispecific

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