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P490 How are thiopurines dosed in Crohn's disease? A novel strategy, maximum dose-titration based on the lower limit of leukocyte count and tolerability

机译：P490如何在克罗恩病中提出硫嘌呤？一种新的策略，基于白细胞计数和耐受性下限的最大剂量滴定

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W. Moon; T.O. Kim; S.J. Park; M.I. Park; H.H. Kim;
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年度 2013
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1. Thiopurines Dosed to a Therapeutic 6-Thioguanine Level in Combination with Adalimumab Are More Effective Than Subtherapeutic Thiopurine-based Combination Therapy or Adalimumab Monotherapy During Induction and Maintenance in Patients with Long-standing Crohn's Disease [J] . Kariyawasam Viraj C., Ward Mark G., Blaker Paul A., Inflammatory bowel diseases . 2017,第9期

机译：在长期克罗恩病的患者的诱导和维护期间，与Adalimueab的治疗性6-硫代胍水平给予治疗性6-硫核苷酸水平的硫嘌呤比患者诱导和维护期间更有效
2. Thiopurines prevented surgical recurrence in patients with Crohn's disease after intestinal resection: Strategy based on risk stratification [J] . Guo Jing, Chen Bai‐li, Chen Zhi‐hui, Journal of gastroenterology and hepatology . 2018,第3期

机译：硫嘌呤预防肠切除后克罗恩病患者的手术复发：基于风险分层的战略
3. Sustained clinical benefit and tolerability of methotrexate monotherapy after thiopurine therapy in patients with Crohn's disease. [J] . Margien L Seinen, Cyriel Y Ponsioen, Nanne K H de Boer, Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association . 2013,第6期

机译：克罗恩病患者接受硫嘌呤治疗后甲氨蝶呤单一疗法的持续临床获益和耐受性。
4. A dose escalating placebo controlled double blind single dose and multidose safety and tolerability study of fontolizumab a humanised anti‐interferon γ antibody in patients with moderate to severe Crohns disease [O] . W Reinisch, D W Hommes, G Van Assche, 2006

机译：人源化抗干扰素γ抗体Fontolizumab在中至重度克罗恩病患者中的剂量递增安慰剂对照双盲单剂量和多剂量安全性和耐受性研究
5. Thiopurines Dosed to a Therapeutic 6-Thioguanine Level in Combination with Adalimumab Are More Effective Than Subtherapeutic Thiopurine-based Combination Therapy or Adalimumab Monotherapy During Induction and Maintenance in Patients with Long-standing Crohnʼs Disease [O] . Viraj C. Kariyawasam, Mark G. Ward, Paul A. Blaker, 2017

机译：在长期克罗恩病患者的诱导和维护期间，与Adapulimueab的治疗性6-硫桃竹水平与患者的硫氟胺的联合疗法或患者的嗜毒素单药治疗更有效

P490 How are thiopurines dosed in Crohn's disease? A novel strategy, maximum dose-titration based on the lower limit of leukocyte count and tolerability

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