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A Conformational Restriction Strategy for the Identification of a Highly Selective Pyrimido-pyrrolo-oxazine mTOR Inhibitor

机译：用于鉴定高选择性嘧啶-Pyrrolo-吡咯 - 吡咯 - 吡咯醇抑制剂的构象限制策略

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Chiara Borsari; Denise Rageot; Alix Dall’Asen; Thomas Bohnacker; Anna Melone; Alexander M. Sele; Eileen Jackson; Jean-Baptiste Langlois; Florent Beaufils; Paul Hebeisen; Doriano Fabbro; Petra Hillmann; Matthias P. Wymann;
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1. A Conformational Restriction Strategy for the Identification of a Highly Selective Pyrimido-pyrrolo-oxazine mTOR Inhibitor [J] . Borsari Chiara, Rageot Denise, DallAsen Alix, Journal of Medicinal Chemistry . 2019,第18期

机译：用于鉴定高选择性嘧啶-Pyrrolo-吡咯 - 吡咯 - 吡咯醇抑制剂的构象限制策略
2. Discovery of highly potent human deoxyuridine triphosphatase inhibitors based on the conformation restriction strategy [J] . Miyahara S., Miyakoshi H., Yokogawa T., Journal of Medicinal Chemistry . 2012,第11期

机译：基于构象限制策略发现高效人脱氧尿苷三磷酸酶抑制剂
3. Cyclopropane-based conformational restriction of GABA by a stereochemical diversity-oriented strategy: Identification of an efficient lead for potent inhibitors of GABA transports [J] . NakadaK., YoshikawaM., IdeS., Bioorganic and medicinal chemistry . 2013,第17期

机译：面向立体化学多样性的策略，基于环丙烷的GABA构象限制：鉴定有效抑制GABA转运的有效铅
4. Development of RNAi technology to selectively inhibit mTORC2 in breast cancer [C] . Thomas Werfel, Dana Brantley-Sieders, Meredith Jackson, World biomaterials congress . 2016

机译：RNAi技术的发展，选择性抑制乳腺癌中的mTORC2
5. Strategies to 'Hydrophobize' Systemic siRNA Vectors and Selectively Inhibit mTORC2 in Breast Tumors Through RNA Interference [D] . Werfel, Thomas Anthony. 2017

机译：“疏水化”系统性siRNA载体并通过RNA干扰选择性抑制乳腺癌中mTORC2的策略
6. Conformational restriction of a type II FMS inhibitor leading to discovery of 5-methyl-N-(2-aryl-1H-benzodimidazo-5-yl)isoxazole-4-carboxamide analogues as selective FLT3 inhibitors [O] . Daseul Im, Hyungwoo Moon, Jingwoong Kim, 2019

机译：构象限制II型FMS抑制剂导致发现5-甲基-N-（2-芳基-1H-苯并d咪唑基-5-基）异恶唑-4-羧酰胺类似物作为选择性FLT3抑制剂
7. A Conformational Restriction Strategy for the Identification of a Highly Selective Pyrimido-pyrrolo-oxazine mTOR Inhibitor [O] . -1

机译：用于鉴定高选择性嘧啶-Pyrrolo-吡咯 - 吡咯 - 吡咯醇抑制剂的构象限制策略

A Conformational Restriction Strategy for the Identification of a Highly Selective Pyrimido-pyrrolo-oxazine mTOR Inhibitor

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