The Swine Influenza Model Based Optimization (SIMBO) family is a newly introduced speedy optimization technique having the adaptive features in its mechanism. In this paper, the authors modified the SIMBO to make the algorithm further quicker. As the SIMBO family is faster, it is a better option for searching the basin. Thus, it is utilized in local searches in developing the proposed memetic algorithms (MAs). The MA has a faster speed compared to SIMBO with the balance in exploration and exploitation. So, MAs have small tradeoffs in convergence velocity for comprehensively optimizing the numerical standard benchmark test bed having functions with different properties. The utilization of SIMBO in the local searching is inherently the exploitation of better characteristics of the algorithms employed for the hybridization. The developed MA is applied to eliminate the power line interference (PLI) from the biomedical signal ECG with the use of adaptive filter whose weights are optimized by the MA. The inference signal required for adaptive filter is obtained using the selective reconstruction of ECG from the intrinsic mode functions (IMFs) of empirical mode decomposition (EMD).
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